Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists
dc.contributor.author | Gosnell, Blake A. | en_US |
dc.contributor.author | Grace, Martha | en_US |
dc.contributor.author | Billington, Charles J. | en_US |
dc.contributor.author | Levine, Allen S. | en_US |
dc.date.accessioned | 2006-04-07T20:55:43Z | |
dc.date.available | 2006-04-07T20:55:43Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Gosnell, Blake A., Grace, Martha, Billington, Charles J., Levine, Allen S. (1989)."Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists." Life Sciences 45(1): 31-40. <http://hdl.handle.net/2027.42/28109> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-4779C79-1GH/2/269b8231cb1ebec24850557814e4221a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28109 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2545990&dopt=citation | en_US |
dc.description.abstract | The potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The selective mu receptor agonist Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAGO) caused a larger increase in intake in diabetic rats than in controls. In both groups feeding responses were greater on the fourth day of daily injections than on the first day. The delta receptor agonist [D-Ser2,Leu5]-enkephalin-Thr6 (DSLET) stimulated intake in controls but not in diabetics. However, the elevated baseline and large variability in intake of the diabetics in this experiment prevent drawing a conclusion on diabetes-induced changes in the potency of this peptide. No differences between controls and diabetics were apparent in the feeding responses to U50,488H, a selective kappa receptor agonist. These data suggest that diabetes may differentially affect the classes of opioid receptors or the binding of ligands to these receptors. | en_US |
dc.format.extent | 586991 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, 8D8806/UH/Box 0116, Ann Arbor, MI 48109-0116, USA | en_US |
dc.contributor.affiliationother | Neuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN, 55417, USA | en_US |
dc.contributor.affiliationother | Neuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN, 55417, USA | en_US |
dc.contributor.affiliationother | Neuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN, 55417, USA | en_US |
dc.identifier.pmid | 2545990 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28109/1/0000558.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(89)90432-3 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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