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Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists

dc.contributor.authorGosnell, Blake A.en_US
dc.contributor.authorGrace, Marthaen_US
dc.contributor.authorBillington, Charles J.en_US
dc.contributor.authorLevine, Allen S.en_US
dc.date.accessioned2006-04-07T20:55:43Z
dc.date.available2006-04-07T20:55:43Z
dc.date.issued1989en_US
dc.identifier.citationGosnell, Blake A., Grace, Martha, Billington, Charles J., Levine, Allen S. (1989)."Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists." Life Sciences 45(1): 31-40. <http://hdl.handle.net/2027.42/28109>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-4779C79-1GH/2/269b8231cb1ebec24850557814e4221aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28109
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2545990&dopt=citationen_US
dc.description.abstractThe potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The selective mu receptor agonist Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAGO) caused a larger increase in intake in diabetic rats than in controls. In both groups feeding responses were greater on the fourth day of daily injections than on the first day. The delta receptor agonist [D-Ser2,Leu5]-enkephalin-Thr6 (DSLET) stimulated intake in controls but not in diabetics. However, the elevated baseline and large variability in intake of the diabetics in this experiment prevent drawing a conclusion on diabetes-induced changes in the potency of this peptide. No differences between controls and diabetics were apparent in the feeding responses to U50,488H, a selective kappa receptor agonist. These data suggest that diabetes may differentially affect the classes of opioid receptors or the binding of ligands to these receptors.en_US
dc.format.extent586991 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleEffects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonistsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan, 8D8806/UH/Box 0116, Ann Arbor, MI 48109-0116, USAen_US
dc.contributor.affiliationotherNeuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN, 55417, USAen_US
dc.contributor.affiliationotherNeuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN, 55417, USAen_US
dc.contributor.affiliationotherNeuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN, 55417, USAen_US
dc.identifier.pmid2545990en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28109/1/0000558.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(89)90432-3en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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