Synthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography
dc.contributor.author | Poupeye, E. | en_US |
dc.contributor.author | Counsell, Raymond E. | en_US |
dc.contributor.author | De Leenheer, A. | en_US |
dc.contributor.author | Slegers, G. | en_US |
dc.contributor.author | Goethals, P. | en_US |
dc.date.accessioned | 2006-04-07T20:56:03Z | |
dc.date.available | 2006-04-07T20:56:03Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Poupeye, E., Counsell, R. E., De Leenheer, A., Slegers, G., Goethals, P. (1989)."Synthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 40(1): 57-61. <http://hdl.handle.net/2027.42/28118> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6X3S-46Y3F0T-73/2/63ffd6e5c49ac768a232e4aadcf4dfb1 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28118 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2540122&dopt=citation | en_US |
dc.description.abstract | A no-carrier added synthesis of [11C]thymidine from cyclotron produced [11C]methyl iodide is presented. The bis-silylated derivative of the lithium salt of 5-bromo-2'-deoxyuridine is treated with [11C]methyl iodide in THF at -50[deg]C giving 20-30 mCi [11C]thymidine in a 40-70% radiochemical yield. Purification is performed by reversed phase chromatography on a C18 column. The whole procedure takes 25 min and the specific activity is about 20-30 mCi/[mu]mol at the end of the synthesis. | en_US |
dc.format.extent | 415930 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Synthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, M 6322 Medical Science Building 1, The University of Michigan, Medical School, Ann Arbor, MI 48109-0624, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, M 6322 Medical Science Building 1, The University of Michigan, Medical School, Ann Arbor, MI 48109-0624, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratoria voor Medische Biochemie en voor Klinische Analyse, Rijksuniversiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgium | en_US |
dc.contributor.affiliationother | Laboratorium voor Analytische Chemie, Faculteit Farmaceutische Wetenschappen, Rijksuniversiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgium | en_US |
dc.contributor.affiliationother | Instituut voor Nucleaire Wetenschappen, Faculteit Farmaceutische Wetenschappen, Rijksuniversiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgium | en_US |
dc.identifier.pmid | 2540122 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28118/1/0000567.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2889(89)90174-3 | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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