Gas chromatographic determination of gallopamil and norgallopamil in human plasma
dc.contributor.author | Ruggirello, Donald A. | en_US |
dc.contributor.author | Noonan, Patrick K. | en_US |
dc.contributor.author | Gonzalez, Mario A. | en_US |
dc.contributor.author | Ho, Paul | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.date.accessioned | 2006-04-07T20:56:12Z | |
dc.date.available | 2006-04-07T20:56:12Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Ruggirello, Donald A., Noonan, Patrick K., Gonzalez, Mario A., Ho, Paul, Wagner, John G. (1989)."Gas chromatographic determination of gallopamil and norgallopamil in human plasma." Journal of Chromatography B: Biomedical Sciences and Applications 487(): 73-80. <http://hdl.handle.net/2027.42/28122> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TG9-44BNNGK-44/2/418793e27182981ae29acd5c4477f388 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28122 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2715276&dopt=citation | en_US |
dc.description.abstract | A highly sensitive gas chromatographic assay is described for the simultaneous determination of gallopamil, a calcium channel blocking agent, and its major metabolite, norgallopamil. A multi-step extraction procedure is employed followed by on-column capillary gas chromatographic analysis using nitrogen-selective detection. Acetylation of norgallopamil is performed to enable accurate quantification of the metabolite. Linearity was achieved over the range 1-50 ng/ml for both analytes. Assay specificity, precision and accuracy were investigated. | en_US |
dc.format.extent | 508786 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Gas chromatographic determination of gallopamil and norgallopamil in human plasma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, c/o Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, c/o Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationother | Department of Biopharmaceutics, Schering Research, 1500 S.W. 66th Avenue, Pembroke Pines, FL 33023 U.S.A. | en_US |
dc.contributor.affiliationother | Department of Biopharmaceutics, Schering Research, 1500 S.W. 66th Avenue, Pembroke Pines, FL 33023 U.S.A. | en_US |
dc.contributor.affiliationother | Department of Biopharmaceutics, Schering Research, 1500 S.W. 66th Avenue, Pembroke Pines, FL 33023 U.S.A. | en_US |
dc.identifier.pmid | 2715276 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28122/1/0000572.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0378-4347(00)83008-X | en_US |
dc.identifier.source | Journal of Chromatography B: Biomedical Sciences and Applications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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