Xylamine enhances pineal gland N-acetyltransferase activity in vitro
dc.contributor.author | Haak, Katherine A. | en_US |
dc.contributor.author | Torres, German | en_US |
dc.contributor.author | Garvey, Patricia L. | en_US |
dc.contributor.author | Bronstein, David M. | en_US |
dc.contributor.author | Cho, Arthur K. | en_US |
dc.contributor.author | Lytle, Loy D. | en_US |
dc.date.accessioned | 2006-04-07T20:56:16Z | |
dc.date.available | 2006-04-07T20:56:16Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Haak, Katherine A., Torres, German, Garvey, Patricia L., Bronstein, David M., Cho, Arthur K., Lytle, Loy D. (1989)."Xylamine enhances pineal gland N-acetyltransferase activity in vitro." General Pharmacology: The Vascular System 20(1): 77-80. <http://hdl.handle.net/2027.42/28124> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T71-475P5JJ-147/2/7d2440bb01e68ed9efab49345fad8e86 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28124 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2565274&dopt=citation | en_US |
dc.description.abstract | 1. 1. The action of N-2'-chloroethyl-N-ethyl-2-methyl benzylamine (xylamine) on rat pineal gland sympathetic innervation was examined.2. 2. This alkylating agent caused a concentration-dependent increase in pineal gland N-acetyltransferase (NAT) activity in neurologically intact pineal glands that was suppressed in glands previously subjected to bilateral superior cervical ganglionectomy.3. 3. Xylamine-induced elevations in NAT activity were attenuated by [beta]-noradrenergic antagonist drugs but not by [alpha]-noradrenergic antagonist drugs.4. 4. Since pineal gland uptake of radiolabelled norepinephrine (NE) was impaired by xylamine, the drug may increase pineal gland NAT activity by inhibiting NE reuptake into the presynaptic nerve terminal, thereby increasing the amount of the neurotransmitter available to stimulate pinealocyte [beta]-noradrenoceptors. | en_US |
dc.format.extent | 321222 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Xylamine enhances pineal gland N-acetyltransferase activity in vitro | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A | en_US |
dc.contributor.affiliationother | Laboratory of Psychopharmacology, Department of Psychology, University of California, Santa Barbara, CA 93106, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Psychopharmacology, Department of Psychology, University of California, Santa Barbara, CA 93106, U.S.A. | en_US |
dc.contributor.affiliationother | International Ophthalmic, Laguna Hills, CA 92651, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90024, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Psychopharmacology, Department of Psychology, University of California, Santa Barbara, CA 93106, U.S.A. | en_US |
dc.identifier.pmid | 2565274 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28124/1/0000574.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0306-3623(89)90064-5 | en_US |
dc.identifier.source | General Pharmacology: The Vascular System | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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