Vascular endothelial cell killing by combinations of membrane-active agents and hydrogen peroxide
dc.contributor.author | Ginsburg, Issac | en_US |
dc.contributor.author | Gibbs, Douglas F. | en_US |
dc.contributor.author | Schuger, Lucia | en_US |
dc.contributor.author | Johnson, Kent J. | en_US |
dc.contributor.author | Ryan, Una S. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.contributor.author | Varani, James | en_US |
dc.date.accessioned | 2006-04-07T20:58:39Z | |
dc.date.available | 2006-04-07T20:58:39Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Ginsburg, Issac, Gibbs, Douglas F., Schuger, Lucia, Johnson, Kent J., Ryan, Una S., Ward, Peter A., Varani, James (1989)."Vascular endothelial cell killing by combinations of membrane-active agents and hydrogen peroxide." Free Radical Biology and Medicine 7(4): 369-376. <http://hdl.handle.net/2027.42/28188> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T38-47NVNW3-GY/2/4ed7491f28e4044e380973ea2742a274 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28188 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2558061&dopt=citation | en_US |
dc.description.abstract | Previous studies have demonstrated that a number of membrane-active agents are capable of binding to the surface of polymorphonuclear leukocytes (PMN) resulting in an augmentation of superoxide anion and hydrogen peroxide (H2O2) production in response to soluble stimuli. It is now demonstrated that these same membrane-active agents can bind to the surface of endothelial cells and enhance their susceptibility to killing by H2O2. Membrane-active agents which are capable of synergizing with H2O2 include cationic proteins, cationic poly-amino acids, lysophosphatides and enzymes which are capable of degrading membrane phospholipids (e.g., phospholipase C, phospholipase A2 and streptolysin S). In each case, treatment of the target cells with the membrane-active agent and H2O2 produces greater damage than the sum of the damage produced by either agent separately. Since inflammatory lesions, particularly sites of bacterial infection, may contain a rich mixture of cationic substances, phospholipases and phospholipid breakdown products, these substances may contribute to the tissue damage observed at sites of inflammation by enhancing endothelial cell sensitivity to PMN-generated H2O2 as well as by augmenting the generation of H2O2 by PMNs. | en_US |
dc.format.extent | 692688 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Vascular endothelial cell killing by combinations of membrane-active agents and hydrogen peroxide | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | The Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | The Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | The Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | The Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | The Department of Oral Biology, Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel | en_US |
dc.contributor.affiliationother | The Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, U.S.A. | en_US |
dc.identifier.pmid | 2558061 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28188/1/0000640.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0891-5849(89)90123-8 | en_US |
dc.identifier.source | Free Radical Biology and Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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