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Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorCarey, James E.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorHaka, Michael S.en_US
dc.contributor.authorHutchins, Gary D.en_US
dc.contributor.authorSherman, Phillip S.en_US
dc.contributor.authorKuhl, David E.en_US
dc.date.accessioned2006-04-07T20:59:28Z
dc.date.available2006-04-07T20:59:28Z
dc.date.issued1989en_US
dc.identifier.citationKilbourn, Michael R., Carey, James E., Koeppe, Robert A., Haka, Michael S., Hutchins, Gary D., Sherman, Phil S., Kuhl, David E. (1989)."Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 16(6): 569-573. <http://hdl.handle.net/2027.42/28208>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B7GH9-4C00NBD-3B/2/38c383686720250f3275d2f20b14bb67en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28208
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2606712&dopt=citationen_US
dc.description.abstractThe in vivo charactersitics of a new radiotracer, [18F]GBR 13119, have been examined. Full body biodistribution in rats has been determined and the expected human dosimetry calculated. Pharmacological specificity of in vivo regional brain distribution in rats was examined. Blockage of specific binding was accomplished by dopamine reuptake inhibitors but no effect was observed for pretreatment with serotonin or norepinephrine reuptake inhibitors. Preliminary examination of rat blood shows the presence of radiolabeled metabolites, which can be rapidly identified using bonded-phase (Sep-Pak) chromatography. Finally, the striatum of living primates has been imaged using PET and i.v. administration of [18F]GBR 13119. These results represent the intermediate steps in the development of [18F]GBR 13119 as a radiotracer for the study of the dopamine uptake system in man.en_US
dc.format.extent687662 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBiodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivoen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid2606712en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28208/1/0000661.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2897(89)90072-Xen_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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