Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A
dc.contributor.author | Norum, Robert A. | en_US |
dc.contributor.author | Lafreniere, Ronald G. | en_US |
dc.contributor.author | O'Neal, Lawrence W. | en_US |
dc.contributor.author | Nikolai, Thomas F. | en_US |
dc.contributor.author | Delaney, J. P. | en_US |
dc.contributor.author | Sisson, James C. | en_US |
dc.contributor.author | Sobol, Hagay | en_US |
dc.contributor.author | Lenoir, Gilbert M. | en_US |
dc.contributor.author | Ponder, Bruce A. J. | en_US |
dc.contributor.author | Willard, Huntington F. | en_US |
dc.contributor.author | Jackson, Charles E. | en_US |
dc.date.accessioned | 2006-04-10T13:36:07Z | |
dc.date.available | 2006-04-10T13:36:07Z | |
dc.date.issued | 1990-10 | en_US |
dc.identifier.citation | Norum, Robert A., Lafreniere, Ronald G., O'Neal, Lawrence W., Nikolai, Thomas F., Delaney, J. P., Sisson, James C., Sobol, Hagay, Lenoir, Gilbert M., Ponder, Bruce A. J., Willard, Huntington F., Jackson, Charles E. (1990/10)."Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A." Genomics 8(2): 313-317. <http://hdl.handle.net/2027.42/28372> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DXB997-7D/2/733bc8273d89df798c72f3b0e665587f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28372 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1979053&dopt=citation | en_US |
dc.description.abstract | The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that MEN 2B patients have neuromas of the mucous membranes. MEN2A has been linked to RBP3, D10S5, FNRB, D10S15, and D10Z1 near the centromere of chromosome 10. We examined linkage between MEN2B and RFLPs on chromosome 10 in all available members in two or three generations of 14 kindreds. The centromere marker D10Z1 was linked to MEN2B with a peak lod score of 5.42 at [theta] = 0.02. One possible recombinant was observed between D10Z1 and MEN2B. Multipoint analysis of RFLPs at FNRB, D10Z1, RBP3, and D10S15 gave a peak lod score of 7.12 at the midpoint between D10Z1 and RBP3 on the long arm (band q11). The most likely gene order FNRB-D10Z1-MEN2B was 27 times more likely than MEN2B-FNRB-D10Z1 and times more likely than FNRB-MEN2B-D10Z1. Additional data will be required to establish the order of these loci with confidence. | en_US |
dc.format.extent | 576753 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Clinical and Molecular Genetics Division, Department of Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA | en_US |
dc.contributor.affiliationother | Department of Genetics, Stanford University, Stanford, California, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, St. John's Mercy Medical Center, St. Louis, Missouri, USA | en_US |
dc.contributor.affiliationother | Section of Endocrinology, Department of Medicine, Marshfield Clinic, Marshfield, Wisconsin, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, University of Minnesota Hospitals, Minneapolis, Minnesota, USA | en_US |
dc.contributor.affiliationother | International Agency for Research on Cancer, Lyon, France | en_US |
dc.contributor.affiliationother | International Agency for Research on Cancer, Lyon, France | en_US |
dc.contributor.affiliationother | CRC Human Cancer Genetics Research Group, University of Cambridge, Cambridge, England | en_US |
dc.contributor.affiliationother | Department of Genetics, Stanford University, Stanford, California, USA | en_US |
dc.contributor.affiliationother | Clinical and Molecular Genetics Division, Department of Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA | en_US |
dc.identifier.pmid | 1979053 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28372/1/0000137.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(90)90287-5 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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