Effects of daily oral m-Chlorophenylpiperazine in elderly depressed patients initial experience with a serotonin agonist
dc.contributor.author | Mellow, Alan M. | en_US |
dc.contributor.author | Lawlor, Brian A. | en_US |
dc.contributor.author | Sunderland, Trey | en_US |
dc.contributor.author | Mueller, Edward A. | en_US |
dc.contributor.author | Molchan, Susan E. | en_US |
dc.contributor.author | Murphy, Dennis L. | en_US |
dc.date.accessioned | 2006-04-10T13:36:24Z | |
dc.date.available | 2006-04-10T13:36:24Z | |
dc.date.issued | 1990-10-01 | en_US |
dc.identifier.citation | Mellow, Alan M., Lawlor, Brian A., Sunderland, Trey, Mueller, Edward A., Molchan, Susan E., Murphy, Dennis L. (1990/10/01)."Effects of daily oral m-Chlorophenylpiperazine in elderly depressed patients initial experience with a serotonin agonist." Biological Psychiatry 28(7): 588-594. <http://hdl.handle.net/2027.42/28379> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4S-484N5VR-W/2/5e5bdef9406b091876486c25014dd330 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28379 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2223928&dopt=citation | en_US |
dc.description.abstract | Six patients (mean age 62.5 +/- 7.6 years) with major depression were treated for 2 weeks with the serotonin agonist m-chlorophenylpiperazine (m-CPP), 80 mg/day in a double-blind, placebo-controlled, crossover-design pilot study. Two patients showed clinically significant improvement in depressive symptoms during active drug treatment, whereas two others showed modest effects. All patients tolerated the drug, with no major side effects and no changes in vital signs or in liver, renal, thyroid, or hematological function. Further studies are needed to determine the characteristics of the possible antidepressant effects of m-CPP; such work may yield greater understanding of the role of serotonin in affective and other psychiatric disorders. | en_US |
dc.format.extent | 658458 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of daily oral m-Chlorophenylpiperazine in elderly depressed patients initial experience with a serotonin agonist | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, Geropsychiatry Program, University of Michigan Medical Center, Ann Arbor, MI 48104-1687, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA | en_US |
dc.contributor.affiliationother | Laboratory of Clinical Science, Unit on Geriatric Psychopharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA | en_US |
dc.contributor.affiliationother | Rutland Mental Health Services, Inc., Rutland, VT 05702, USA | en_US |
dc.contributor.affiliationother | Laboratory of Clinical Science, Unit on Geriatric Psychopharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA | en_US |
dc.contributor.affiliationother | Laboratory of Clinical Science, Unit on Geriatric Psychopharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA | en_US |
dc.identifier.pmid | 2223928 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28379/1/0000146.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-3223(90)90396-J | en_US |
dc.identifier.source | Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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