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Analgesic, anesthetic, and respiratory effects of the competitive (NMDA) antagonist CGS 19755 in rhesus monkeys
dc.contributor.authorFrance, Charles P.en_US
dc.contributor.authorWinger, Gail D.en_US
dc.contributor.authorWoods, James H.en_US
dc.date.accessioned2006-04-10T13:36:59Z
dc.date.available2006-04-10T13:36:59Z
dc.date.issued1990-09-03en_US
dc.identifier.citationFrance, Charles P., Winger, Gail D., Woods, James H. (1990/09/03)."Analgesic, anesthetic, and respiratory effects of the competitive (NMDA) antagonist CGS 19755 in rhesus monkeys." Brain Research 526(2): 355-358. <http://hdl.handle.net/2027.42/28393>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-483SK5W-8G/2/606b12c441c534501ff90eab87f9b9bben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28393
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2257491&dopt=citationen_US
dc.description.abstractThe competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex.en_US
dc.format.extent363952 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAnalgesic, anesthetic, and respiratory effects of the competitive (NMDA) antagonist CGS 19755 in rhesus monkeysen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.; Department of Psychology, The University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.contributor.affiliationumDepartment of Psychology, The University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.; Department of Pharmacology, The University of Michigan, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.identifier.pmid2257491en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28393/1/0000168.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(90)91247-Een_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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