Mechanisms for muscarinic inhibition of somatostatin release from canine fundic D cells
dc.contributor.author | Chiba, Tsutomu | en_US |
dc.contributor.author | Yamada, Tadataka | en_US |
dc.date.accessioned | 2006-04-10T13:37:16Z | |
dc.date.available | 2006-04-10T13:37:16Z | |
dc.date.issued | 1990-09 | en_US |
dc.identifier.citation | Chiba, Tsutomu, Yamada, Tadataka (1990/09)."Mechanisms for muscarinic inhibition of somatostatin release from canine fundic D cells." Metabolism 39(9, Supplement 2): 122-124. <http://hdl.handle.net/2027.42/28400> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WN4-4C2SHDV-73/2/947ceb43fda5e98bcc07d970ae1a70d6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28400 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1976205&dopt=citation | en_US |
dc.description.abstract | We undertook the present studies to explore the mechanisms by which carbachol inhibits the release of somatostatin-like immunoreactivity (SLI) from D cells. D cells were isolated from canine fundic mucosa by collagenase/EDTA dispersion followed by counterflow elutriation. Carbachol inhibited the release of SLI induced by forskolin, dibutyryl 3':5' cyclic adenosine monophosphate (cAMP), pentagastrin (PG), and 12-0-tetradecanoyl-phorbol-13-acetate in a fashion that could be prevented by pertussis toxin (PT) pretreatment of the D cells. Pertussis toxin also prevented the carbachol-induced inhibition of forskolin-stimulated cAMP generation and PG-stimulated [Ca2+]i mobilization. These data indicate that pertussin toxin sensitive inhibitory guanine nucleotide binding proteins mediate many of carbachol's inhibitory actions on D cells. | en_US |
dc.format.extent | 434442 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mechanisms for muscarinic inhibition of somatostatin release from canine fundic D cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | the Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationother | Division of Gerontology, Department of Internal Medicine Kobe University School of Medicine, Kobe, Japan | en_US |
dc.identifier.pmid | 1976205 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28400/1/0000175.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0026-0495(90)90228-5 | en_US |
dc.identifier.source | Metabolism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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