Regulation of epidermal growth factor and insulin-like growth factor I receptors by estradiol and progesterone in normal and neoplastic endometrial cell cultures,
dc.contributor.author | Reynolds, R. Kevin | en_US |
dc.contributor.author | Talavera, Francisco | en_US |
dc.contributor.author | Roberts, James A. | en_US |
dc.contributor.author | Hopkins, Michael P. | en_US |
dc.contributor.author | Menon, K. M. J. | en_US |
dc.date.accessioned | 2006-04-10T13:37:59Z | |
dc.date.available | 2006-04-10T13:37:59Z | |
dc.date.issued | 1990-09 | en_US |
dc.identifier.citation | Reynolds, R. Kevin, Talavera, Francisco, Roberts, James A., Hopkins, Michael P., Menon, K. M. J. (1990/09)."Regulation of epidermal growth factor and insulin-like growth factor I receptors by estradiol and progesterone in normal and neoplastic endometrial cell cultures,." Gynecologic Oncology 38(3): 396-406. <http://hdl.handle.net/2027.42/28418> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG6-4C52KRW-C7/2/5a814f7445b16ee6673d58c7a479cb7d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28418 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2172119&dopt=citation | en_US |
dc.description.abstract | Growth factors are polypeptides which regulate cell proliferation through binding to specific receptor proteins. Normal and neoplastic human endometrium have been shown to express epidermal growth factor (EGF) and insulin-like growth factor I (IGF-1) receptors. Endometrial cell cultures were used to test modulation of EGF and IGF-1 receptors in response to steroid hormones. Endometrial gland and stroma cells were separated by enzymatic dispersion and were incubated in medium containing estradiol (10, 100, or 1000 pg/ml) or progesterone (1, 10, or 100 ng/ml) followed by radioligand assays. Normal endometrial cultures (n = 6) treated with estradiol demonstrated 40% less EGF binding than control cultures (P n = 2) demonstrated decreased EGF binding compared with normal endometrium (P P < 0.05). These data illustrate effects of steroid hormones upon growth factor receptors in human endometrium, and suggest involvement of growth factors in the regulation of normal and neoplastic endometrial growth. | en_US |
dc.format.extent | 2249169 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Regulation of epidermal growth factor and insulin-like growth factor I receptors by estradiol and progesterone in normal and neoplastic endometrial cell cultures, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.contributor.affiliationum | Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.contributor.affiliationum | Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.contributor.affiliationum | Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.contributor.affiliationum | Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.identifier.pmid | 2172119 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28418/1/0000195.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-8258(90)90081-U | en_US |
dc.identifier.source | Gynecologic Oncology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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