Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal subjects,
dc.contributor.author | Cameron, Oliver G. | en_US |
dc.contributor.author | Smith, Charles B. | en_US |
dc.contributor.author | Lee, Myung Ae | en_US |
dc.contributor.author | Hollingsworth, Peggie J. | en_US |
dc.contributor.author | Hill, Elizabeth M. | en_US |
dc.contributor.author | Curtis, George C. | en_US |
dc.date.accessioned | 2006-04-10T13:40:10Z | |
dc.date.available | 2006-04-10T13:40:10Z | |
dc.date.issued | 1990-07-01 | en_US |
dc.identifier.citation | Cameron, Oliver G., Smith, Charles B., Lee, Myung A., Hollingsworth, Peggie J., Hill, Elizabeth M., Curtis, George C. (1990/07/01)."Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal subjects,." Biological Psychiatry 28(1): 3-20. <http://hdl.handle.net/2027.42/28473> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4S-484N6VF-C7/2/ea6b665b34b486a2d28fc932e3b6f3a4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28473 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2165422&dopt=citation | en_US |
dc.description.abstract | In order to evaluate adrenergic function in anxiety disorders, platelet alpha2-adrenergic binding parameters and supine and standing blood pressure, pulse, and venous plasma epinephrine and norepinephrine were determined in patients with panic attacks or generalized anxiety disorder and in normal subjects. The maximum number of binding sites (Bmax) for the partial agonist tritiated clonidine was significantly lower for both patient groups than for normal subjects, and the Bmax for the antagonist tritiated yohimbine was significantly lower for panic patients. There were no other substantive differences across groups. Prior exposure to psychotrophic drugs might account for the results for clonidine binding, but not for yphimbine. The Bmax for clonodine was correlated with norepinephrine increases upon standing and, for panic patients, with the severity of full unexpected panic attacks. These data provide further evidence of adrenergic receptor abnormalities in people with anxiety disorders. | en_US |
dc.format.extent | 1953493 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal subjects, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 2165422 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28473/1/0000264.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-3223(90)90427-4 | en_US |
dc.identifier.source | Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.