Effects of plasma on PGI2 release from prolonged perfused canine veins
dc.contributor.author | Brunkwall, Jan S. | en_US |
dc.contributor.author | Stanley, James C. | en_US |
dc.contributor.author | Graham, Linda M. | en_US |
dc.contributor.author | Burkel, William E. | en_US |
dc.contributor.author | Bergqvist, David | en_US |
dc.date.accessioned | 2006-04-10T13:40:26Z | |
dc.date.available | 2006-04-10T13:40:26Z | |
dc.date.issued | 1990-07-01 | en_US |
dc.identifier.citation | Brunkwall, Jan S, Stanley, James C, Graham, Linda M, Burkel, William E, Bergqvist, David (1990/07/01)."Effects of plasma on PGI2 release from prolonged perfused canine veins." Thrombosis Research 59(1): 61-67. <http://hdl.handle.net/2027.42/28480> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1C-4C06GVJ-HG/2/23c3b36cf4d8192aa7f9de9fe5975629 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28480 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2119077&dopt=citation | en_US |
dc.description.abstract | Prostacyclin release from endothelial cells in culture appears increased by the presence of plasma, but occurrence of a similar phenomenon in intact vessels has not been established. In the present investigation release of 6-keto-PGF1[alpha], the stable breakdown product of prostacyclin, was quantitated from canine veins perfused ex vivo for 15 minute periods, using three different perfusates: 1) Hank's balanced salt solution (HBSS), 2) 20% platelet poor plasma (PPP) derived from heparinized blood, in HBSS, and 3) 20% PPP in HBSS with added arachidonic acid (AA). No differences in initial 6-keto-PGF1[alpha] release existed among the three perfusates. However, PPP and PPP + AA solutions were associated with lesser declines in release, than occurred with HBSS alone, these differences being statistically significant after 60 min of perfusion (p<0.05). When PPP derived from heparinized and citrated blood rather than from only heparinized blood was used, there was a significantly lower release of prostacyclin (p<0.05). The latter may be due to citrate binding of calcium. These data indicate that autologous plasma does not alter initial prostacyclin release from freshly harvested canine veins, but that it weakens the decline in release usually following prolonged periods of perfusion. | en_US |
dc.format.extent | 652222 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of plasma on PGI2 release from prolonged perfused canine veins | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, University of Lund, Malmö General Hospital, Malmö, Sweden | en_US |
dc.contributor.affiliationother | Department of Surgery, University of Lund, Malmö General Hospital, Malmö, Sweden | en_US |
dc.identifier.pmid | 2119077 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28480/1/0000274.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0049-3848(90)90271-D | en_US |
dc.identifier.source | Thrombosis Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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