Activation of human T cell clones through the UM4D4/CDw60 surface antigen
dc.contributor.author | Fox, David A. | en_US |
dc.contributor.author | Davis, William | en_US |
dc.contributor.author | Zeldes, Wendy | en_US |
dc.contributor.author | Kan, Li | en_US |
dc.contributor.author | Higgs, Jay | en_US |
dc.contributor.author | Duby, Allan D. | en_US |
dc.contributor.author | Holoshitz, Joseph | en_US |
dc.date.accessioned | 2006-04-10T13:41:43Z | |
dc.date.available | 2006-04-10T13:41:43Z | |
dc.date.issued | 1990-07 | en_US |
dc.identifier.citation | Fox, David A., Davis, William, Zeldes, Wendy, Kan, Li, Higgs, Jay, Duby, Allan D., Holoshitz, Joseph (1990/07)."Activation of human T cell clones through the UM4D4/CDw60 surface antigen." Cellular Immunology 128(2): 480-489. <http://hdl.handle.net/2027.42/28512> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCF-4F686TR-D/2/d8a22b2854bb181bbbce626b16b5e369 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28512 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2141550&dopt=citation | en_US |
dc.description.abstract | UM4D4 is a recently defined antigen that is expressed on ~25% of peripheral blood T cells, but on the majority of T cells in inflammatory synovial fluid. Anti-UM4D4 activates peripheral blood T cells in the presence of accessory cells and/or phorbol ester. UM4D4 has been assigned to a new antigen cluster termed CDw60. The present study examined the ability of anti-UM4D4 to activate T cell clones derived from the synovial fluid of patients with rheumatoid arthritis. UM4D4 was expressed at varying levels on both lectin-generated and antigen-specific clones, including clones of CD4+, CD8+, and CD4-CD8- phenotypes. Anti-UM4D4 used in soluble form as a single stimulus was typically mitogenic for the CD4+ and some of the CD8+ clones, but not for the CD4-CD8- clones. Phorbol ester boosted the response to anti-UM4D4 in some clones, had no effect in others, and diminished the responses in some cases. In contrast to anti-UM4D4, anti-CD3 was generally not mitogenic in soluble form, although it was mitogenic when conjugated to beads. The data show that T cell clones derived from an inflammatory T cell infiltrate can be readily activated through the UM4D4/CDw60 antigen. | en_US |
dc.format.extent | 666190 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Activation of human T cell clones through the UM4D4/CDw60 surface antigen | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Rackham Arthritis Research Unit, and Multipurpose Arthritis Center, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Rackham Arthritis Research Unit, and Multipurpose Arthritis Center, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Rackham Arthritis Research Unit, and Multipurpose Arthritis Center, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Rackham Arthritis Research Unit, and Multipurpose Arthritis Center, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Rackham Arthritis Research Unit, and Multipurpose Arthritis Center, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Medicine, Stanford University, Stanford, California, U.S.A.; Department of Internal Medicine, Rackham Arthritis Research Unit, and Multipurpose Arthritis Center, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationother | Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A. | en_US |
dc.identifier.pmid | 2141550 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28512/1/0000309.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0008-8749(90)90042-P | en_US |
dc.identifier.source | Cellular Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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