View Item 

Show simple item record

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

dc.contributor.authorRichardson, Bruce C.en_US
dc.contributor.authorLiebling, Michael R.en_US
dc.contributor.authorHudson, Jerry L.en_US
dc.date.accessioned2006-04-10T13:43:13Z
dc.date.available2006-04-10T13:43:13Z
dc.date.issued1990-06en_US
dc.identifier.citationRichardson, Bruce C., Liebling, Michael R., Hudson, Jerry L. (1990/06)."CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation." Clinical Immunology and Immunopathology 55(3): 368-381. <http://hdl.handle.net/2027.42/28550>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WCK-4BJW42M-1PB/2/956191d73433794e976906bbbfef58aaen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28550
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1692774&dopt=citationen_US
dc.description.abstractThe DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.en_US
dc.format.extent1050394 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUCLA School of Medicine, Los Angeles, California 90024, USA; University of Michigan, Ann Arbor, Michigan 48109-0531, USA.en_US
dc.contributor.affiliationumUCLA School of Medicine, Los Angeles, California 90024, USA; University of Michigan, Ann Arbor, Michigan 48109-0531, USA.en_US
dc.contributor.affiliationumUCLA School of Medicine, Los Angeles, California 90024, USA; University of Michigan, Ann Arbor, Michigan 48109-0531, USA.en_US
dc.identifier.pmid1692774en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28550/1/0000349.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0090-1229(90)90125-Aen_US
dc.identifier.sourceClinical Immunology and Immunopathologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000349.pdf
Size:
1.001MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.