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-[3H]Glutamate labels the metabotropic excitatory amino acid receptor in rodent brain
dc.contributor.authorCha, Jang-Ho J.en_US
dc.contributor.authorMakowiec, Richard L.en_US
dc.contributor.authorPenney, John B.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2006-04-10T13:43:54Z
dc.date.available2006-04-10T13:43:54Z
dc.date.issued1990-05-18en_US
dc.identifier.citationCha, Jang-Ho J., Makowiec, Richard L., Penney, John B., Young, Anne B. (1990/05/18)."-[3H]Glutamate labels the metabotropic excitatory amino acid receptor in rodent brain." Neuroscience Letters 113(1): 78-83. <http://hdl.handle.net/2027.42/28567>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485RNJ8-1K1/2/514e328988e484e82b239f35affc2e71en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28567
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1973276&dopt=citationen_US
dc.description.abstractA quantitative autoradiographic assay for a novel -[3H]glutamate binding site in rodent brain has been developed. Binding to this site was distinguished by its high affinity for quisqualate (QA), ibotenate, glutamate and trans-1-amino-cyclopentyl-1,3-dicarboxylic acid (trans-ACPD), but low affinity for [RS]-[alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate and (NMDA). `AMPA-insensitive, QA-sensitive [3H]glutamate binding' (AiQsGB) had a heterogeneous distribution in rat brain with high levels observed in molecular layer of cerebellum, striatum, and lateral septum. AiQsGB was reduced in molecular layer of cerebellum in mice lacking Purkinje cells. AiQsGB appears to represent binding to the `metabotropic' neuronal excitatory amino acid receptor linked to phosphoinositide metabolism.en_US
dc.format.extent351601 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.title-[3H]Glutamate labels the metabotropic excitatory amino acid receptor in rodent brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Program and Department of Neurology, University of Michigan, Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.contributor.affiliationumNeuroscience Program and Department of Neurology, University of Michigan, Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.contributor.affiliationumNeuroscience Program and Department of Neurology, University of Michigan, Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.contributor.affiliationumNeuroscience Program and Department of Neurology, University of Michigan, Ann Arbor, MI 48104-1687, U.S.A.en_US
dc.identifier.pmid1973276en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28567/1/0000369.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(90)90498-Xen_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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