Multiplicity of depressive episodes: Phenomenological and neuroendocrine correlates
dc.contributor.author | Gurguis, George N. M. | en_US |
dc.contributor.author | Meador-Woodruff, James H. | en_US |
dc.contributor.author | Haskett, Roger F. | en_US |
dc.contributor.author | Greden, John F. | en_US |
dc.date.accessioned | 2006-04-10T13:44:03Z | |
dc.date.available | 2006-04-10T13:44:03Z | |
dc.date.issued | 1990-05-15 | en_US |
dc.identifier.citation | Gurguis, George N. M., Meador-Woodruff, James H., Haskett, Roger F., Greden, John F. (1990/05/15)."Multiplicity of depressive episodes: Phenomenological and neuroendocrine correlates." Biological Psychiatry 27(10): 1156-1164. <http://hdl.handle.net/2027.42/28571> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4S-484N6KR-8X/2/16cde7573db3cdfb68cdd3a0e27b1620 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28571 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2340324&dopt=citation | en_US |
dc.description.abstract | Sixty-four patients with a Research Diagnostic Criteria (RDC) diagnosis of major depressive disorder were categorized into three groups based on their number of depressive episodes (DE): Gr 1 (1 DE), n = 16, Gr II (2-4 DE), n = 25; and Gr III (5 or more DE), n = 23. All patients were nonsuppressors after 1 mg dexamethasone suppression test (DST) prior to the start of treatment. Patients were monitored during the course of their treatment using serial Hamilton Depression scores and post-DST plasma cortisol levels. A proportionately equal number of patients in the three groups had a favorable outcome, i.e., the number of depressive episodes did not predict recovery. Despite favorable clinical outcome, patients with higher numbers of depressive episodes had significantly higher post-DST plasma cortisol levels that were above the supressive range (greater than 5 [mu]g/dl). Patients with a higher number of depressive episodes had a significantly shorter duration of index episodes and were younger at first depressive episode than patients in the other two groups. These results, however, were confounded with polarity, with a higher number of bipolars in Gr III than in the other two groups. Results are discussed in light of phenomenological and psychoendocrine findings of earlier studies. | en_US |
dc.format.extent | 675276 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Multiplicity of depressive episodes: Phenomenological and neuroendocrine correlates | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Unit of the Michigan Depression Program, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Clinical Unit of the Michigan Depression Program, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Clinical Unit of the Michigan Depression Program, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Clinical Unit of the Michigan Depression Program, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 2340324 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28571/1/0000374.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-3223(90)90052-4 | en_US |
dc.identifier.source | Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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