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Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat
dc.contributor.authorDracopoli, Nicholas C.en_US
dc.contributor.authorMeisler, Miriam H.en_US
dc.date.accessioned2006-04-10T13:44:34Z
dc.date.available2006-04-10T13:44:34Z
dc.date.issued1990-05en_US
dc.identifier.citationDracopoli, Nicholas C., Meisler, Miriam H. (1990/05)."Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat." Genomics 7(1): 97-102. <http://hdl.handle.net/2027.42/28584>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DP5JHW-2D/2/3894e23d3b60dc4ed647c6f09afb4d55en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28584
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1692298&dopt=citationen_US
dc.description.abstractThe human amylase gene cluster includes a (CA)n repeat sequence immediately upstream of the [gamma]-actin pseudogene associated with the AMY2B gene. Analysis of this (CA)n repeat by PCR amplification of genomic DNA from the 40 families of the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel revealed extensive polymorphism. A total of six alleles with (CA)n lengths of 16-21 repeats were found. The average heterozygosity for this polymorphism was 0.70. Multipoint linkage analysis showed that the amylase gene cluster is located distal to the nerve growth factor [beta]-subunit gene (NGFB) and is within 1 cM of the anonymous locus D1S10. The amylase (CA)n repeat provides a convenient marker for both the physical and the genetic maps of human chromosome 1p.en_US
dc.format.extent935578 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeaten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherDepartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA; Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.en_US
dc.identifier.pmid1692298en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28584/1/0000391.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(90)90523-Wen_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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