The synthesis and chemistry of certain anthelmintic benzimidazoles
dc.contributor.author | Townsend, Leroy B. | en_US |
dc.contributor.author | Wise, Dean S. | en_US |
dc.date.accessioned | 2006-04-10T13:46:42Z | |
dc.date.available | 2006-04-10T13:46:42Z | |
dc.date.issued | 1990-04 | en_US |
dc.identifier.citation | Townsend, L. B., Wise, D. S. (1990/04)."The synthesis and chemistry of certain anthelmintic benzimidazoles." Parasitology Today 6(4): 107-112. <http://hdl.handle.net/2027.42/28637> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TB8-49NH4PV-GC/2/9784e5d19b23cb9d0497b30ce7325970 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28637 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15463311&dopt=citation | en_US |
dc.description.abstract | A basis for interest in the benzimidazole ring system as a nucleus from which to develop potential chemotherapeutic agents was established in the 1950s when it was found that 5,6-dimethyl-l-([alpha]-D-ribofuranosyl)benzimidazole (I) was an integral part of the structure of vitamin B12. As a result of these interests and extensive studies, one health related arena that has benefited greatly has been the treatment of parasitic diseases. The discovery of thiabendazole in 1961 further spurred chemists around the world to design and synthesize several thousand benzimidazoles for screening for anthelmintic activity but less than twenty of them have reached commercial use. Much of this work has been done by pharmaceutical companies and is only reported in the patent literature. In this paper, Leroy Townsend and Dean Wise review the development of some of the synthetic methods that have been critical to the preparation of the benzimidazoles of anthelmintic importance. Only a few molecules that demonstrate the processes are discussed here, but numerous reviews of the synthesis and chemistry of other benzimidazoles are available1-3. | en_US |
dc.format.extent | 858227 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The synthesis and chemistry of certain anthelmintic benzimidazoles | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, College of Pharmacy and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, College of Pharmacy and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 15463311 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28637/1/0000451.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0169-4758(90)90226-T | en_US |
dc.identifier.source | Parasitology Today | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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