Effect of optic nerve lesions and intraocular colchicine on cell proliferation in the germinal zone of the optic tectum and in the torus longitudinalis in the goldfish
dc.contributor.author | Davis, Roger E. | en_US |
dc.date.accessioned | 2006-04-10T13:47:59Z | |
dc.date.available | 2006-04-10T13:47:59Z | |
dc.date.issued | 1990-03-26 | en_US |
dc.identifier.citation | Davis, Roger E. (1990/03/26)."Effect of optic nerve lesions and intraocular colchicine on cell proliferation in the germinal zone of the optic tectum and in the torus longitudinalis in the goldfish." Brain Research 512(1): 46-53. <http://hdl.handle.net/2027.42/28669> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-483SX1F-396/2/b1d9cdf9256ee7b851c48af4b5eabeb4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28669 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2337808&dopt=citation | en_US |
dc.description.abstract | Postembryonic development of the optic tectum occurs in part through proliferation of cells in the germinal zone located at the caudal edges of each lobe. Autoradiography experiments by others have shown that [3H]thymidine labeling in the germinal zone is decreased following optic nerve crush or enucleation and restored above normal levels during optic nerve regeneration. The present autoradiography experiments examined the relationship between retinal innervation and the rate mitotic activity in the tectum germinal zone and in the torus longitudinalis. The fish received optic nerve crush to temporarily deafferent the tectum, enucleation for permanent deafferentiation, or an intraocular injection of 0.01-1.0 [mu]g of colchicine to reversibly inhibit axonal transport in the optic nerve. Thymidine labeling in the tectum germinal zone showed that nerve crush resulted in decreased mitotic activity in most fish within 6 days followed by recovery by 21 days; enucleation decreased mitotic activity more uniformly and for more than 42 days with recovery by 84 days postaxotomy; colchicine produced a dose-dependent inhibition of mitotic activity which was reversed by 42 days postinjection. Axonal transport was restored by 42 days postinjection. In the torus longitudinalis, nerve crush produced a brief increase in mitotic activity followed by a return to a normal; enucleation and colchicine resulted in a lasting decrease in mitotic activity and atrophy indicating a loss of cells or neuropil. The data are consistent with the proposal that cell proliferation in the tectum germinal zone is stimulated by the accretion of fibers from developing retinal ganglion cells. Axonal transport of cellular materials in mature retinal fibers may also be involved. The results further suggest that the torus longitudinalis undergoes postembryonic development apace the optic tectum, and that its growth, like that of the tectum, is stimulated by the eye. | en_US |
dc.format.extent | 1034875 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of optic nerve lesions and intraocular colchicine on cell proliferation in the germinal zone of the optic tectum and in the torus longitudinalis in the goldfish | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-1687, U.S.A. | en_US |
dc.identifier.pmid | 2337808 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28669/1/0000486.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(90)91168-G | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.