Accumulated glutamate levels in the synaptic vesicle are not maintained in the absence of active transport
dc.contributor.author | Carlson, Martha D. | en_US |
dc.contributor.author | Ueda, Tetsufumi | en_US |
dc.date.accessioned | 2006-04-10T13:48:25Z | |
dc.date.available | 2006-04-10T13:48:25Z | |
dc.date.issued | 1990-03-14 | en_US |
dc.identifier.citation | Carlson, Martha D., Ueda, Tetsufumi (1990/03/14)."Accumulated glutamate levels in the synaptic vesicle are not maintained in the absence of active transport." Neuroscience Letters 110(3): 325-330. <http://hdl.handle.net/2027.42/28680> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-482RCMN-J/2/506beff64f6c9d29f0b5c9c549a77dfd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28680 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1970147&dopt=citation | en_US |
dc.description.abstract | We have investigated factors which may affect accumulated glutamate levels in synaptic vesicles and glutamate efflux. Agents which dissipate the electrochemical proton gradient resulted in a rapid reduction of steady-state vesicular glutamate levels, which was prevented by N-ethylmaleimide. Glutamate efflux was found to occur even in the presence of an electrochemical proton gradient, but was effectively inhibited by N-ethylmaleimide. These results suggest that accumulated glutamate levels in synaptic vesicles are not maintained unless glutamate is taken up continuously by an active transport mechanism, and they could provide an explanation for the lack of convincing evidence for the enrichment of endogenous glutamate in isolated synaptic vesicles. | en_US |
dc.format.extent | 377136 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Accumulated glutamate levels in the synaptic vesicle are not maintained in the absence of active transport | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan, Ann Arbor, MI, U.S.A.; Department of Psychiatry, The University of Michigan, Ann Arbor, MI, U.S.A.; Mental Health Research Institute, The University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.identifier.pmid | 1970147 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28680/1/0000497.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(90)90868-A | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.