Effect of anticholinergic medication on positive and negative symptoms in medication-free schizophrenic patients
dc.contributor.author | Tandon, Rajiv | en_US |
dc.contributor.author | Mann, Nancy A. | en_US |
dc.contributor.author | Eisner, William H. | en_US |
dc.contributor.author | Coppard, Nancy | en_US |
dc.date.accessioned | 2006-04-10T13:49:29Z | |
dc.date.available | 2006-04-10T13:49:29Z | |
dc.date.issued | 1990-03 | en_US |
dc.identifier.citation | Tandon, Rajiv, Mann, Nancy A., Eisner, William H., Coppard, Nancy (1990/03)."Effect of anticholinergic medication on positive and negative symptoms in medication-free schizophrenic patients." Psychiatry Research 31(3): 235-241. <http://hdl.handle.net/2027.42/28707> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TBV-45XSSD3-1R/2/fe2ea363375f7c3b6e7561df4e2a03e6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28707 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2333355&dopt=citation | en_US |
dc.description.abstract | It is generally assumed that anticholinergic drugs have no effects on schizophrenic symptomatology. A few studies, however, indicate that anticholinergic agents aggravate psychotic symptoms and antagonize therapeutic effects of neuroleptics in schizophrenic patients; more recently, some investigators have observed that these agents appear to benefit negative symptoms. In an effort to resolve this issue, we studied the effects of 2 days of treatment with biperiden on positive and negative symptoms in 15 medication-free schizophrenic patients. Positive symptoms increased significantly, while there was a trend toward a decrease in negative symptoms. The implications of these findings for the role of the cholinergic system in schizophrenia are discussed. | en_US |
dc.format.extent | 610652 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of anticholinergic medication on positive and negative symptoms in medication-free schizophrenic patients | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Schizophrenia Program and Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Schizophrenia Research Program and Department of Psychiatric Nursing, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Schizophrenia Research Program and Department of Psychiatric Nursing, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Schizophrenia Research Program and Department of Psychiatric Nursing, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 2333355 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28707/1/0000527.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1781(90)90092-J | en_US |
dc.identifier.source | Psychiatry Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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