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Disparate gene expression of chemotactic cytokines by human mononuclear phagocytes

dc.contributor.authorStrieter, Robert M.en_US
dc.contributor.authorChensue, Stephen W.en_US
dc.contributor.authorStandiford, Theodore J.en_US
dc.contributor.authorBasha, Michael A.en_US
dc.contributor.authorShowell, H. J.en_US
dc.contributor.authorKunkel, Steven L.en_US
dc.date.accessioned2006-04-10T13:51:01Z
dc.date.available2006-04-10T13:51:01Z
dc.date.issued1990-01-30en_US
dc.identifier.citationStrieter, R. M., Chensue, S. W., Standiford, T. J., Basha, M. A., Showell, H. J., Kunkel, S. L. (1990/01/30)."Disparate gene expression of chemotactic cytokines by human mononuclear phagocytes." Biochemical and Biophysical Research Communications 166(2): 886-891. <http://hdl.handle.net/2027.42/28746>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DMX9RM-14V/2/6fd7081a05c152e8494d71cf276f311den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28746
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2405859&dopt=citationen_US
dc.description.abstractChemotactic cytokines are becoming increasingly recognized as important participants in the coordinate recruitment of specific inflammatory cells. In this manuscript we present data demonstrating that LPS challenged human mononuclear phagocytic cells can express mRNA for neutrophil chemotactic factor/interleukin-8 (NCF/IL-8), but do not express mRNA for monocyte chemotactic protein (MCP). The expression of NCF/IL-8 mRNA was time and dose dependent. This identical stimulus response was also found in peripheral blood neutrophils. These studies demonstrate a disparate production of chemotactic cytokines by macrophages and exemplify the dynamic nature of the chemotactic response.en_US
dc.format.extent752029 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDisparate gene expression of chemotactic cytokines by human mononuclear phagocytesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Pulmonary Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDivision of Pulmonary Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDivision of Pulmonary Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDivision of Pulmonary Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Immunology, Pfizer Central Research, Groton, Connecticut, USA; Division of Pulmonary Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USAen_US
dc.identifier.pmid2405859en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28746/1/0000576.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(90)90893-Ren_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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