Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood
dc.contributor.author | Castaneda, Edward | en_US |
dc.contributor.author | Whishaw, Ian Q. | en_US |
dc.contributor.author | Lermer, Leonard | en_US |
dc.contributor.author | Robinson, Terry E. | en_US |
dc.date.accessioned | 2006-04-10T13:51:06Z | |
dc.date.available | 2006-04-10T13:51:06Z | |
dc.date.issued | 1990-01-29 | en_US |
dc.identifier.citation | Castaneda, Edward, Whishaw, Ian Q., Lermer, Leonard, Robinson, Terry E. (1990/01/29)."Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood." Brain Research 508(1): 30-39. <http://hdl.handle.net/2027.42/28748> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-483SWPG-360/2/b1309779dd710a8fd876ec9f03495a0d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28748 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1692503&dopt=citation | en_US |
dc.description.abstract | Rats depleted of dopamine (DA) by intraventricular 6-hydroxydopamine (6-OHDA) in infancy show behavioral impairments as adults, but their basic sensory-motor functions and feeding abilities are intact; at least relative to the pronounced deficits seen in rats given similar v treatment in adulthood. Here we investigate whether presynaptic changes culminating in enhanced DA release are present in adult rats that received neonatal damage, and whether these are of a sufficient magnitude to contribute to the sparing of function. We used microdialysis in rats during the resting state, walking on a treadmill, and after a systemic injection of amphetamine. It was found that neonatal 6-OHDA produced a nearly complete (<1% of control) depletion of DA in postmortem tissue, but this was not accompanied by a comparable decline in the basal extracellular concentrations of DA, which were only reduced by 12-54% of control values. In contrast, the extracellular concentrations of DA metabolites were greatly reduced, reflecting the post-mortem tissue concentrations of DA. Nevertheless, neonatally depleted animals were markedly deficient in their ability to respond to an amphetamine challenge, both behaviorally and in their ability to further increase DA release. Thus, following neonatal DA depletion there appear to be extensive changes in the few remaining DA terminals that are sufficient to maintain relatively high extracellular (and presumably synaptic) concentrations of DA during the resting state, but the capacity of the remaining DA neurons to respond to increased demand is very limited. This presynaptic compensatory response may play a role in the sparing of behavioral function seen following neonatal damage. | en_US |
dc.format.extent | 1042624 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Psychology, University of Lethbridge, Lethbridge, Alta., Canada | en_US |
dc.contributor.affiliationother | Department of Psychology, University of Lethbridge, Lethbridge, Alta., Canada | en_US |
dc.contributor.affiliationother | Department of Psychology, University of Lethbridge, Lethbridge, Alta., Canada | en_US |
dc.identifier.pmid | 1692503 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28748/1/0000578.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(90)91113-U | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.