Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA
dc.contributor.author | Lucey, Michael R. | en_US |
dc.contributor.author | Kolars, Joseph C. | en_US |
dc.contributor.author | Merion, Robert M. | en_US |
dc.contributor.author | Campbell, Darrell A. | en_US |
dc.contributor.author | Aldrich, M. | en_US |
dc.contributor.author | Watkins, Paul B. | en_US |
dc.date.accessioned | 2006-04-10T13:51:27Z | |
dc.date.available | 2006-04-10T13:51:27Z | |
dc.date.issued | 1990-01-06 | en_US |
dc.identifier.citation | Lucey, M. R., Kolars, J. C., Merion, R. M., Campbell, D. A., Aldrich, M., Watkins, P. B. (1990/01/06)."Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA." The Lancet 335(8680): 11-15. <http://hdl.handle.net/2027.42/28757> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1B-49M0Y3G-1PJ/2/bafe182984b512ddb12350542b7f2f06 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28757 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1967328&dopt=citation | en_US |
dc.description.abstract | A 40-year-old male liver allograft recipient had neurological dysfunction and renal failure while his cyclosporin blood levels were in the therapeutic range; these features recurred on rechallenge. The hypothesis that this toxic effect might have resulted from abnormal metabolism of cyclosporin by liver cytochrome P-450 IIIA was investigated with the [14C]erythromycin breath test, which is a measure of this enzyme's activity. P-450 IIIA activity was decreased compared with that in controls, including other liver transplant recipients. Pretreatment with rifampicin, an inducer of P-450 IIIA, increased enzyme activity. After treatment with rifampicin the patient could be rechallenged with cyclosporin at a dose almost twice that which had previously been toxic. The patient died during a second transplantation and the microsomal content of P-450 IIIA was found to be low in the first transplant. | en_US |
dc.format.extent | 740723 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, Neurology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, Neurology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, Neurology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, Neurology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, Neurology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, Neurology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 1967328 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28757/1/0000587.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0140-6736(90)90137-T | en_US |
dc.identifier.source | The Lancet | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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