Positive-ion thermospray liquid chromatography--mass spectrometry: detection of organic acidurias
dc.contributor.author | Buchanan, Douglas N. | en_US |
dc.contributor.author | Muenzer, Joseph | en_US |
dc.contributor.author | Thoene, Jess G. | en_US |
dc.date.accessioned | 2006-04-10T13:51:30Z | |
dc.date.available | 2006-04-10T13:51:30Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Buchanan, Douglas N., Muenzer, Joseph, Thoene, Jess G. (1990)."Positive-ion thermospray liquid chromatography--mass spectrometry: detection of organic acidurias." Journal of Chromatography B: Biomedical Sciences and Applications 534(): 1-11. <http://hdl.handle.net/2027.42/28758> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TG9-44BP3TV-1/2/52c05811f21b4c155c6d6525498100f3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28758 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1709942&dopt=citation | en_US |
dc.description.abstract | Positive-ion thermospray liquid chromatography--mass spectrometry (TSP-LC-MS) is used to detect organic acids via the direct injection of untreated urine from newborns and infants. Two methods are reported for the separation of organic acids. The separation of urinary organic acids is effected in either an acidic, pH 2.5 sulfuric acid, or a non-acidic, 0.05 M ammonium acetate, pH 6.8, mobile phase. Use of pH 2.5 sulfuric acid and an HPX-87H organic acid column produces better separation but has less sensitivity than the use of 0.05 M ammonium acetate, pH 6.8 and a C18 column. Positive ion TSP-LC-MS has been used to detect methylmalonic aciduria, 3-hydroxy-3-methylglutaric aciduria, propionic aciduria, isovaleric aciduria and argininosuccinic aciduria. | en_US |
dc.format.extent | 634470 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Positive-ion thermospray liquid chromatography--mass spectrometry: detection of organic acidurias | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Biochemical Genetics and Metabolism, The University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Biochemical Genetics and Metabolism, The University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Biochemical Genetics and Metabolism, The University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.identifier.pmid | 1709942 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28758/1/0000588.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0378-4347(00)82143-X | en_US |
dc.identifier.source | Journal of Chromatography B: Biomedical Sciences and Applications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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