View Item 

Show simple item record

Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation
dc.contributor.authorBucan, Majaen_US
dc.contributor.authorZimmer, M.en_US
dc.contributor.authorWhaley, W. Lanceen_US
dc.contributor.authorPoustka, A.en_US
dc.contributor.authorYoungman, S.en_US
dc.contributor.authorAllitto, Bernice A.en_US
dc.contributor.authorOrmondroyd, E.en_US
dc.contributor.authorSmith, B.en_US
dc.contributor.authorPohl, Tia M.en_US
dc.contributor.authorMacDonald, Marcy E.en_US
dc.date.accessioned2006-05-10T15:39:42Z
dc.date.available2006-05-10T15:39:42Z
dc.date.issued1990-01en_US
dc.identifier.citationBucan, M., Zimmer, M., Whaley, W. L., Poustka, A., Youngman, S., Allitto, B. A., Ormondroyd, E., Smith, B., Pohl, T. M., MacDonald, M. (1990/01)."Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation." Genomics 6(1): 1-15. <http://hdl.handle.net/2027.42/28761>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DNHPF9-5V/2/2da0c42b078eb05d89521a731fa7f740en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28761
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2137426&dopt=citationen_US
dc.description.abstractThe gene for Huntington disease, a neurodegenerative disorder with autosomal dominant inheritance, has been localized to the terminal portion of the short arm of human chromosome 4 (4p16.3) by linkage analysis. Since eventual isolation of the gene requires the application of high-resolution genetic analysis coupled with long-range DNA mapping and cloning techniques, we have constructed a physical map of the chromosomal region 4p16.3 using more than 20 independently derived probes. We have grouped these markers into three clusters which have been ordered and oriented by genetic and somatic cell genetic mapping information. The mapped region extends from D4S10 (G8) toward the telomere and covers minimally 5 Mb.en_US
dc.format.extent62978 bytes
dc.format.extent3118 bytes
dc.format.extent2978923 bytes
dc.format.mimetypetext/plain
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.titlePhysical maps of 4p16.3, the area expected to contain the Huntington disease mutationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherno department founden_US
dc.contributor.affiliationotherno department founden_US
dc.contributor.affiliationotherInstitute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Englanden_US
dc.contributor.affiliationotherno department founden_US
dc.contributor.affiliationotherno department founden_US
dc.contributor.affiliationotherZMBH, Im Neuenheimer Feld 282, D-6900, Heidelberg, West Germanyen_US
dc.contributor.affiliationotherImperial Cancer Research Fund, P.O. Box 123, Lincolns Inn Fields, London WC2A3PX, Englanden_US
dc.contributor.affiliationotherno department founden_US
dc.contributor.affiliationotherDepartment of Biological Chemistry, California College of Medicine, University of California, Irvine, California 92717, USAen_US
dc.contributor.affiliationotherInstitute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Englanden_US
dc.identifier.pmid2137426en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28761/3/0000591.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(90)90442-Wen_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000591.pdf
Size:
2.840MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.