Ion-pair chromatography of inositol polyphosphates with N-methylimipramine
dc.contributor.author | Shayman, James A. | en_US |
dc.contributor.author | Barcelon, Florence S. | en_US |
dc.date.accessioned | 2006-04-10T13:53:54Z | |
dc.date.available | 2006-04-10T13:53:54Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Shayman, James A., Barcelon, Florence S. (1990)."Ion-pair chromatography of inositol polyphosphates with N-methylimipramine." Journal of Chromatography B: Biomedical Sciences and Applications 528(): 143-154. <http://hdl.handle.net/2027.42/28818> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TG9-44C9RS9-3N/2/3f78068e8d41dd0f17ac45a637f86ba3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28818 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2200799&dopt=citation | en_US |
dc.description.abstract | A novel counter-ion, N-methylimipramine, was synthesized and utilized in the separation of inositol phosphates by ion-pair chromatography. The structural identity of the counter-ion was documented by nuclear magnetic resonance spectroscopy. This counter-ion was capable of resolving inositol phosphates isocratically by reversed-phase high-performance liquid chromatography. Solvent polarity and ionic strength markedly affected the retention of the polyphosphorylated inositides. pH, however, was less significant in its effects. Injection of inositol trisphosphate paired to N-methylimipramine into a mobile phase containing tetrabutylammonium ions demonstrated free exchange of the inositide between the counter-ions. This counter-ion may therefore prove useful in defining empirically the mechanisms of ion-pair chromatography. | en_US |
dc.format.extent | 855188 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Ion-pair chromatography of inositol polyphosphates with N-methylimipramine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Nephrology, University of Michigan Medical Center and Veterans Administration Medical Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0676 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Nephrology, University of Michigan Medical Center and Veterans Administration Medical Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0676 U.S.A. | en_US |
dc.identifier.pmid | 2200799 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28818/1/0000652.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0378-4347(00)82369-5 | en_US |
dc.identifier.source | Journal of Chromatography B: Biomedical Sciences and Applications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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