Role of O2- in neutrophil recruitment into sites of dermal and pulmonary vasculitis

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dc.contributor.author Warren, Jeffrey S. en_US
dc.contributor.author Yabroff, Karen R. en_US
dc.contributor.author Mandel, David M. en_US
dc.contributor.author Johnson, Kent J. en_US
dc.contributor.author Ward, Peter A. en_US
dc.date.accessioned 2006-04-10T13:54:15Z
dc.date.available 2006-04-10T13:54:15Z
dc.date.issued 1990 en_US
dc.identifier.citation Warren, Jeffrey S., Yabroff, Karen R., Mandel, David M., Johnson, Kent J., Ward, Peter A. (1990)."Role of O2- in neutrophil recruitment into sites of dermal and pulmonary vasculitis." Free Radical Biology and Medicine 8(2): 163-172. <http://hdl.handle.net/2027.42/28827> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6T38-47N6B4K-G0/2/c80b3bd2caa65311a9de4e621ba387ba en_US
dc.identifier.uri http://hdl.handle.net/2027.42/28827
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2158935&dopt=citation en_US
dc.description.abstract Using analogous models of acute dermal vasculities and alveolitis in rats, we have examined the role of oxygen-derived metabolities in the tissue damage associated with neutrophil influx into sites of immune complex deposition. In the lung, as previously reported, catalase and deferoxamine are highly protective, while superoxide dismutase (SOD) has a transient protective effect. The xanthine oxidase inhibitors, allopurinol, and lodoxamide, are also protective. In the skin, neither catalase (which has been covalently linked to the antibody) nor deferoxamine is protective, suggesting that H2O2 and iron are not absolutely required for the development of dermal vasculitis. In the skin, SOD, as well as the inhibitors of xanthine oxidase, have protective effects. These data suggest that the neutrophil-mediated pahtwayws of immune complex injury in the dermal and pulmonary microvascular compartments are fundamentally different.As a measurement of neutrophil accumulation, measurements of myeloperoxidase in tissue extracts have been employed. In both the lung and skin, the protective effects of SOD and the xanthine oxidase inhibitors are paralleled by reductions in neutrophil influx into sites of injury. In contrast, catalase and deferoxamine have no effect on neutrophil accumulation.These data suggest that vascular beds in rat skin and lung are fundamentally different with respect to mechanisms of acute immune complex mediated injury. The data also provide evidence that O2- contributes significantly to the accumulation of neutrophils. en_US
dc.format.extent 813889 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Role of O2- in neutrophil recruitment into sites of dermal and pulmonary vasculitis en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbsecondlevel Chemistry en_US
dc.subject.hlbsecondlevel Chemical Engineering en_US
dc.subject.hlbsecondlevel Biological Chemistry en_US
dc.subject.hlbtoplevel Engineering en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Pathology, The University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, U.S.A. en_US
dc.contributor.affiliationum Department of Pathology, The University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, U.S.A. en_US
dc.contributor.affiliationum Department of Pathology, The University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, U.S.A. en_US
dc.contributor.affiliationum Department of Pathology, The University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, U.S.A. en_US
dc.contributor.affiliationum Department of Pathology, The University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, U.S.A. en_US
dc.identifier.pmid 2158935 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/28827/1/0000661.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0891-5849(90)90089-2 en_US
dc.identifier.source Free Radical Biology and Medicine en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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