Effects of placebo (saline) injections on core temperature in the rat
dc.contributor.author | Dilsaver, Steven C. | en_US |
dc.contributor.author | Majchrzak, Mark J. | en_US |
dc.date.accessioned | 2006-04-10T13:56:20Z | |
dc.date.available | 2006-04-10T13:56:20Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Dilsaver, Steven C., Majchrzak, Mark J. (1990)."Effects of placebo (saline) injections on core temperature in the rat." Progress in Neuro-Psychopharmacology and Biological Psychiatry 14(3): 417-422. <http://hdl.handle.net/2027.42/28880> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TBR-475BH7N-G/2/01491dbe226b74746a310eb50e3122c3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28880 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2359846&dopt=citation | en_US |
dc.description.abstract | 1. Core temperature was telemetrically measured in 15 rats before (i.e., at baseline) and at 10-min intervals for 120 min following the injection of normal saline (1 ml/kg ip) or "no injection."2. The sample exhibited a mean temperature increase of 0.60 +/- 0.10[deg]C(mean +/- SEM) following injection.3. This differed significantly from the mean increase of 0.13 +/- 0.03[deg]C following "no injection" (p 4. The injection of saline (1 ml/kg) affected a mean rise in core temperature of 0.55 +/- 0.07[deg]C (p > 0.000001) in 46 animals in a second experiment.5. These data indicate that routine handling and a simple injection comprise significant and measurable stress which must be controlled in neuropharmacological studies employing a thermoregulation paradigm. | en_US |
dc.format.extent | 405638 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of placebo (saline) injections on core temperature in the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2359846 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28880/1/0000716.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0278-5846(90)90029-G | en_US |
dc.identifier.source | Progress in Neuro-Psychopharmacology and Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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