Regional ontogeny of a unique glutamate recognition site in rat brain: An autoradiographic study
dc.contributor.author | Greenamyre, J. Timothy | en_US |
dc.contributor.author | Higgins, Donald S. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.date.accessioned | 2006-04-10T13:56:29Z | |
dc.date.available | 2006-04-10T13:56:29Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Greenamyre, J. Timothy, Higgins, Donald S., Young, Anne B., Penney, John B. (1990)."Regional ontogeny of a unique glutamate recognition site in rat brain: An autoradiographic study." International Journal of Developmental Neuroscience 8(4): 437-445. <http://hdl.handle.net/2027.42/28884> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T01-485RGTF-1S/2/c7ebf826a1284953157488f255bead10 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28884 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2174635&dopt=citation | en_US |
dc.description.abstract | The developmental pattern of -[3H]glutamate binding to rat brain in the presence of saturating concentrations of unlabeled N-methyl--aspartate (NMDA), kainate (KA) and quisqualate (OQA) was examined in an autoradiographic assay. The unique glutamate binding site defined by this assay displayed four distinct, regionally specific patterns of development. 1. (1) In reticular nucleus of thalamus there was an initial very high level of binding at postnatal day 1 (PND1) followed by a progressive 80% decline in binding during maturation.2. (2) In entorhinal cortex, a progressive 500-1100% increase in binding was seen during development.3. (3) In ventral posterior medial nucleus of thalamus, there was an initial transient 200-300% increase in binding, peaking at PND10, followed by a steady decline in binding.4. (4) In frontal cortex, binding remained relatively stable throughout development. At all stages of development, the distribution of these recognition sites was different from NMDA, KA or QQA receptors. The function of this glutamate binding site remains to be determined, but the distinct regional and temporal patterns of binding suggest that it may be important in normal development of the central nervous system. | en_US |
dc.format.extent | 848591 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Regional ontogeny of a unique glutamate recognition site in rat brain: An autoradiographic study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Neuroscience Lab. Bldg, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Neuroscience Lab. Bldg, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Neuroscience Lab. Bldg, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationother | Departments of Neurology, Neurobiology and Anatomy, and Pharmacology, University of Rochester Medical Center, Rochester, NY 14642, U.S.A. | en_US |
dc.identifier.pmid | 2174635 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28884/1/0000720.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0736-5748(90)90076-E | en_US |
dc.identifier.source | International Journal of Developmental Neuroscience | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.