The participation of coenzyme Q in free radical production and antioxidation
dc.contributor.author | Beyer, Robert E. | en_US |
dc.date.accessioned | 2006-04-10T13:56:57Z | |
dc.date.available | 2006-04-10T13:56:57Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Beyer, Robert E. (1990)."The participation of coenzyme Q in free radical production and antioxidation." Free Radical Biology and Medicine 8(6): 545-565. <http://hdl.handle.net/2027.42/28896> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T38-47N650W-P/2/70a85dedb516eef3381f0908f848e54f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28896 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2193854&dopt=citation | en_US |
dc.description.abstract | Published experimental data pertaining to the participation of coenzyme Q as a site of free radical formation in the mitochondrial electron transfer chain and the conditions required for free radical production have been reviewed critically. The evidence suggests that a component from each of the mitochondrial NADH-coenzyme Q, succinate-coenzyme Q, and coenzyme QH2-cytochrome c reductases (complexes I, II, and III, most likely a nonheme iron-sulfur protein of each complex, is involved in free radical formation. Although the semiquinone form of coenzyme Q may be formed during electron transport, its unpaired electron most likely serves to aid in the dismutation of superoxide radicals instead of participating in free radical formation. Results of studies with electron transfer chain inhibitors make the conclusion dubious that coenzyme Q is a major free radical generator under normal physiological conditions but may be involved in superoxide radical formation during ischemia and subsequent reperfusion. Experiments at various levels of organization including subcellular systems, intact animals, and human subjects in theclinical setting, support the view that coenzyme Q, mainly in its reduced state, may act as an antioxidant protecting a number of cellular membranes from free radical damage. | en_US |
dc.format.extent | 2036805 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The participation of coenzyme Q in free radical production and antioxidation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, The University of Michigan, Ann Arbor, MI 48109-1048, U.S.A. | en_US |
dc.identifier.pmid | 2193854 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28896/1/0000732.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0891-5849(90)90154-B | en_US |
dc.identifier.source | Free Radical Biology and Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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