Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth
dc.contributor.author | Fitzgerald, Mark | en_US |
dc.contributor.author | Chiego, Jr, D. J. | en_US |
dc.contributor.author | Heys, Donald R. | en_US |
dc.date.accessioned | 2006-04-10T13:57:47Z | |
dc.date.available | 2006-04-10T13:57:47Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Fitzgerald, M., Chiego, Jr, D. J., Heys, D. R. (1990)."Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth." Archives of Oral Biology 35(9): 707-715. <http://hdl.handle.net/2027.42/28917> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4J-4BWHK6G-14Y/2/3a08d32e9b756c2082439678a1d7049b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28917 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2091590&dopt=citation | en_US |
dc.description.abstract | Cell migration and replication associated with odontoblast replacement occurring soon after pulp exposure in primate teeth were studied. Class 5 cavity preparations resulting in pulp exposures were restored with a calcium hydroxide-containing capping agent and amalgam. Eighty-four and 96 h after this the animals were injected with 0.5 [mu]Ci/g body wt tritiated thymidine (sp. act. 6.7 Ci/mM). Teeth were extracted 6, 8, 10 and 12 days after treatment. The number of labelled cells as well as the number of grains per labelled cell were counted for odontoblast-like, fibroblast-like and perivascular cells in three 60 x 260 [mu]m zones. These zones represented the odontoblast and cell-free (zone 1), cell-rich (zone 2) and deep pulp (zone 3) areas of normal pulp tissue. Ten sections centred around the mid-point of the exposure were counted for each tooth. Matrix formation and labelled odontoblast-like cells were observed at the interface between the capping agent and the pulp as early as day 8. Other significant findings were: (1) an increase in labelled odontoblast-like cells in zone 1 over time, suggesting a continual influx of differentiating cells; (2) an increase in labelled cells in zone 1 over time with a concurrent decrease in zone 3, suggesting that the influx of cells in zone 1 was from the deeper pulp; and (3) differences in grain counts between zones, treatment times and cell types, indicating that at least two DNA replications had occurred between initial treatment and final odontoblast-like cell differentiation. | en_US |
dc.format.extent | 1164038 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cariology and General Dentistry, The University of Michigan, School of Dentistry, Ann Arbor, MI 48109-1078, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, The University of Michigan, School of Dentistry, Ann Arbor, MI 48109-1078, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Cariology and General Dentistry, The University of Michigan, School of Dentistry, Ann Arbor, MI 48109-1078, U.S.A. | en_US |
dc.identifier.pmid | 2091590 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28917/1/0000754.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0003-9969(90)90093-P | en_US |
dc.identifier.source | Archives of Oral Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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