Synthesis of fluorine-18 labeled GABA uptake inhibitors
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Pavia, Michael R. | en_US |
dc.contributor.author | Gregor, Vlad E. | en_US |
dc.date.accessioned | 2006-04-10T13:57:56Z | |
dc.date.available | 2006-04-10T13:57:56Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Kilbourn, Michael R., Pavia, Michael R., Gregor, Vlad E. (1990)."Synthesis of fluorine-18 labeled GABA uptake inhibitors." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 41(9): 823-828. <http://hdl.handle.net/2027.42/28921> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6X3S-478BP2T-X/2/d0bf164a1730ec319ff27e7e5dbcdf5e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28921 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2176190&dopt=citation | en_US |
dc.description.abstract | The first syntheses of fluorine-18 labeled inhibitors of GABA reuptake [(R,S)-1-{2-{4-[18F]fluorophenyl}phenyl}methoxyethyl]piperidine-3-carboxylic acid, (R,S)-1-{2-(4-[18F]fluorophenyl)(4-fluorophenyl)methoxyethyl}piperidine-3-carboxylic acid, and (R,S)-1-[2-{(4-[18F]trifluoromethyl)phenyl} {(4-trifluoromethyl)phenyl}-methoxyethyl]piperidine-3-carboxylic acid] are described. These N-substituted nipecotic acid derivatives were prepared in no-carrier-added form by the condensation of the appropriately substituted [18F]benzhydryl chlorides (prepared in three steps from [18F]fluoride ion) with N-(2-hydroxyethyl)nipecotic acid ethyl ester, followed by ester hydrolysis. Overall radiochemical yields were 17-28% (corrected, 150 min synthesis time). A simple new method for synthesis of a [18F]trifluoromethyl group by the nucleophilic substitution of a bromodifluoromethyl substituent has also been developed. | en_US |
dc.format.extent | 637872 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Synthesis of fluorine-18 labeled GABA uptake inhibitors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationother | Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationother | Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI 48105, U.S.A. | en_US |
dc.identifier.pmid | 2176190 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28921/1/0000758.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2889(90)90059-P | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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