Caffeine and human cerebral blood flow: A positron emission tomography study

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dc.contributor.author Cameron, Oliver G. en_US
dc.contributor.author Modell, Jack G. en_US
dc.contributor.author Hariharan, M. en_US
dc.date.accessioned 2006-04-10T13:58:40Z
dc.date.available 2006-04-10T13:58:40Z
dc.date.issued 1990 en_US
dc.identifier.citation Cameron, Oliver G., Modell, Jack G., Hariharan, M. (1990)."Caffeine and human cerebral blood flow: A positron emission tomography study." Life Sciences 47(13): 1141-1146. <http://hdl.handle.net/2027.42/28939> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6T99-477GDSB-JG/2/9a7bf9ce0d3ccb1a7f2dce6976d8351d en_US
dc.identifier.uri http://hdl.handle.net/2027.42/28939
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2122148&dopt=citation en_US
dc.description.abstract Positron emission tomography (PET) was used to quantify the effect of caffeine on whole brain and regional cerebral blood flow (CBF) in humans. A mean dose of 250 mg of caffeine produced approximately a 30% decrease in whole brain CBF; regional differences in caffeine effect were not observed. Pre-caffeine CBF strongly influenced the magnitude of the caffeine-induced decrease. Caffeine decreased paCO2 and increased systolic blood pressure significantly; the change in paCO2 did not account for the change in CBF. Smaller increases in diastolic blood pressure, heart rate, plasma epinephrine and norephinephrine, and subjectively reported anxiety were also observed. en_US
dc.format.extent 379859 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Caffeine and human cerebral blood flow: A positron emission tomography study en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Psychiatry, University of Michigan Medical Center, USA en_US
dc.contributor.affiliationum Department of Psychiatry, University of Michigan Medical Center, USA en_US
dc.contributor.affiliationum Department of Psychiatry, University of Michigan Medical Center, USA en_US
dc.identifier.pmid 2122148 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/28939/1/0000776.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0024-3205(90)90174-P en_US
dc.identifier.source Life Sciences en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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