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Caffeine and human cerebral blood flow: A positron emission tomography study

dc.contributor.authorCameron, Oliver G.en_US
dc.contributor.authorModell, Jack G.en_US
dc.contributor.authorHariharan, Meenatshisundananen_US
dc.date.accessioned2006-04-10T13:58:40Z
dc.date.available2006-04-10T13:58:40Z
dc.date.issued1990en_US
dc.identifier.citationCameron, Oliver G., Modell, Jack G., Hariharan, M. (1990)."Caffeine and human cerebral blood flow: A positron emission tomography study." Life Sciences 47(13): 1141-1146. <http://hdl.handle.net/2027.42/28939>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-477GDSB-JG/2/9a7bf9ce0d3ccb1a7f2dce6976d8351den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28939
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2122148&dopt=citationen_US
dc.description.abstractPositron emission tomography (PET) was used to quantify the effect of caffeine on whole brain and regional cerebral blood flow (CBF) in humans. A mean dose of 250 mg of caffeine produced approximately a 30% decrease in whole brain CBF; regional differences in caffeine effect were not observed. Pre-caffeine CBF strongly influenced the magnitude of the caffeine-induced decrease. Caffeine decreased paCO2 and increased systolic blood pressure significantly; the change in paCO2 did not account for the change in CBF. Smaller increases in diastolic blood pressure, heart rate, plasma epinephrine and norephinephrine, and subjectively reported anxiety were also observed.en_US
dc.format.extent379859 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCaffeine and human cerebral blood flow: A positron emission tomography studyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan Medical Center, USAen_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan Medical Center, USAen_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan Medical Center, USAen_US
dc.identifier.pmid2122148en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28939/1/0000776.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(90)90174-Pen_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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