The role of [beta]-blockade therapy for ventricular tachycardia induced with isoproterenol: A prospective analysis
dc.contributor.author | DiCarlo, Jr. , Lorenzo A. | en_US |
dc.contributor.author | Susser, Frank | en_US |
dc.contributor.author | Winston, Stuart A. | en_US |
dc.date.accessioned | 2006-04-10T13:59:06Z | |
dc.date.available | 2006-04-10T13:59:06Z | |
dc.date.issued | 1990-12 | en_US |
dc.identifier.citation | DiCarlo, Jr., Lorenzo A., Susser, Frank, Winston, Stuart A. (1990/12)."The role of [beta]-blockade therapy for ventricular tachycardia induced with isoproterenol: A prospective analysis." American Heart Journal 120(6, Part 1): 1347-1355. <http://hdl.handle.net/2027.42/28950> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BSVJJV-1C5/2/7c19f12e99aa95edfbd7ce3b296e1e6e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28950 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1978977&dopt=citation | en_US |
dc.description.abstract | Isoproterenol is sometimes required for ventricular tachycardia (VT) induction. However, the role of [beta]-blockade for treatment of such VT has not been critically assessed. The use of [beta]-blockade was evaluated prospectively in 14 consecutive patients who required isoproterenol 2.4 +/- 1.3 (+/-S. D.) [mu]g/min to induce sustained monomorphic VT (>30 seconds, or requiring termination due to hemodynamic collapse) after a negative baseline study. The VT mechanisms were enhanced automaticity (group A, six patients), triggered automaticity (group B, three patients), and reentry (group C, five patients). Groups A and B had serial intravenous electropharmacologic tests with propranolol alone (0.2 mg/kg), verapamil alone (0.15 mg/kg), and propranolol plus verapamil, and group C had serial tests with propranolol alone, procainamide or quinidine (class la drug) alone, and propranolol plus a class la drug until VT could no longer be induced. All six patients in group A responded to propranolol alone. In group B, one patient responded to verapamil alone, and two patients responded to propranolol plus verapamil. In group C, three patients responded to propranolol alone, one patient responded to a class la drug alone, and one patient responded to propranolol plus a class la drug. During a follow-up of 7 to 37 (17.9 +/- 10.7) (+/-S. D.) months, VT has not recurred in any patient. Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure. In patients requiring isoproterenol for VT induction, [beta]-blockade alone appears to be effective in preventing reinduction of VT caused by enhanced automaticity. A heterogeneous response occurs when the VT mechanisms are triggered automaticity or reentry. | en_US |
dc.format.extent | 3740865 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The role of [beta]-blockade therapy for ventricular tachycardia induced with isoproterenol: A prospective analysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Cardiac Electrophysiology Laboratory, St. Joseph Mercy Hospital of the Catherine McAuley Health Center, Ann Arbor, Mich., USA; The School of Medicine, University of Michigan, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | The School of Medicine, University of Michigan, Ann Arbor, Mich., USA; Cardiac Electrophysiology Laboratory, St. Joseph Mercy Hospital of the Catherine McAuley Health Center, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | The School of Medicine, University of Michigan, Ann Arbor, Mich., USA; Cardiac Electrophysiology Laboratory, St. Joseph Mercy Hospital of the Catherine McAuley Health Center, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 1978977 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28950/1/0000787.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(90)90247-U | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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