The role of [beta]-blockade therapy for ventricular tachycardia induced with isoproterenol: A prospective analysis

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dc.contributor.author DiCarlo, Jr. , Lorenzo A. en_US
dc.contributor.author Susser, Frank en_US
dc.contributor.author Winston, Stuart A. en_US
dc.date.accessioned 2006-04-10T13:59:06Z
dc.date.available 2006-04-10T13:59:06Z
dc.date.issued 1990-12 en_US
dc.identifier.citation DiCarlo, Jr., Lorenzo A., Susser, Frank, Winston, Stuart A. (1990/12)."The role of [beta]-blockade therapy for ventricular tachycardia induced with isoproterenol: A prospective analysis." American Heart Journal 120(6, Part 1): 1347-1355. <http://hdl.handle.net/2027.42/28950> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6W9H-4BSVJJV-1C5/2/7c19f12e99aa95edfbd7ce3b296e1e6e en_US
dc.identifier.uri http://hdl.handle.net/2027.42/28950
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1978977&dopt=citation en_US
dc.description.abstract Isoproterenol is sometimes required for ventricular tachycardia (VT) induction. However, the role of [beta]-blockade for treatment of such VT has not been critically assessed. The use of [beta]-blockade was evaluated prospectively in 14 consecutive patients who required isoproterenol 2.4 +/- 1.3 (+/-S. D.) [mu]g/min to induce sustained monomorphic VT (&gt;30 seconds, or requiring termination due to hemodynamic collapse) after a negative baseline study. The VT mechanisms were enhanced automaticity (group A, six patients), triggered automaticity (group B, three patients), and reentry (group C, five patients). Groups A and B had serial intravenous electropharmacologic tests with propranolol alone (0.2 mg/kg), verapamil alone (0.15 mg/kg), and propranolol plus verapamil, and group C had serial tests with propranolol alone, procainamide or quinidine (class la drug) alone, and propranolol plus a class la drug until VT could no longer be induced. All six patients in group A responded to propranolol alone. In group B, one patient responded to verapamil alone, and two patients responded to propranolol plus verapamil. In group C, three patients responded to propranolol alone, one patient responded to a class la drug alone, and one patient responded to propranolol plus a class la drug. During a follow-up of 7 to 37 (17.9 +/- 10.7) (+/-S. D.) months, VT has not recurred in any patient. Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure. In patients requiring isoproterenol for VT induction, [beta]-blockade alone appears to be effective in preventing reinduction of VT caused by enhanced automaticity. A heterogeneous response occurs when the VT mechanisms are triggered automaticity or reentry. en_US
dc.format.extent 3740865 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title The role of [beta]-blockade therapy for ventricular tachycardia induced with isoproterenol: A prospective analysis en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Internal Medicine and Specialties en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Cardiac Electrophysiology Laboratory, St. Joseph Mercy Hospital of the Catherine McAuley Health Center, Ann Arbor, Mich., USA; The School of Medicine, University of Michigan, Ann Arbor, Mich., USA. en_US
dc.contributor.affiliationum The School of Medicine, University of Michigan, Ann Arbor, Mich., USA; Cardiac Electrophysiology Laboratory, St. Joseph Mercy Hospital of the Catherine McAuley Health Center, Ann Arbor, Mich., USA en_US
dc.contributor.affiliationum The School of Medicine, University of Michigan, Ann Arbor, Mich., USA; Cardiac Electrophysiology Laboratory, St. Joseph Mercy Hospital of the Catherine McAuley Health Center, Ann Arbor, Mich., USA en_US
dc.identifier.pmid 1978977 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/28950/1/0000787.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0002-8703(90)90247-U en_US
dc.identifier.source American Heart Journal en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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