Inhibin secretion during the rat estrous cycle: Relationships to FSH secretion and FSH beta subunit mRNA concentrations
dc.contributor.author | Haisenleder, Daniel J. | en_US |
dc.contributor.author | Ortolano, G. A. | en_US |
dc.contributor.author | Jolly, D. | en_US |
dc.contributor.author | Dalkin, A. C. | en_US |
dc.contributor.author | Landefeld, Thomas D. | en_US |
dc.contributor.author | Vale, Wylie W. | en_US |
dc.contributor.author | Marshall, John C. | en_US |
dc.date.accessioned | 2006-04-10T13:59:22Z | |
dc.date.available | 2006-04-10T13:59:22Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Haisenleder, DJ, Ortolano, GA, Jolly, D, Dalkin, AC, Landefeld, TD, Vale, WW, Marshall, JC (1990)."Inhibin secretion during the rat estrous cycle: Relationships to FSH secretion and FSH beta subunit mRNA concentrations." Life Sciences 47(19): 1769-1773. <http://hdl.handle.net/2027.42/28957> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-4751S6W-264/2/aa7f28f4c55663849376157d0d9d8c80 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28957 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2123512&dopt=citation | en_US |
dc.description.abstract | Serum inhibin and FSH and FSH beta subunit mRNA levels were measured at 3h intervals throughout the 4 day estrous cycle in female rats and hourly between 1000 and 2400 h of proestrus. On proestrus, serum inhibin concentrations fell during the late morning-early afternoon, then increased transiently during the late afternoon gonadotropin surges. Inhibin levels decreased during the late evening of proestrus, coincident with the FSH surge-related rise in FSH beta mRNA levels. Serum inhibin remained relatively stable during estrus and early metestrus, but rose during the late evening of metestrus and remained elevated until early diestrus. FSH beta mRNA levels were elevated on late estrus and early metestrus and declined during the evening of metestrus as serum inhibin levels increased. These data show that concetrations of serum inhibin change during the estrous cycle and that a general inverse relationship exist between serum inhibin and FSH levels and FSH beta mRNA concentrations in the pituitary. This suggests that inhibin may inhibit FSH beta gene expression and FSH secretion during the 4 day cycle in female rats. | en_US |
dc.format.extent | 334050 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Inhibin secretion during the rat estrous cycle: Relationships to FSH secretion and FSH beta subunit mRNA concentrations | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Internal Medicine, and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Internal Medicine, and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Internal Medicine, and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Internal Medicine, and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Division of Endocrinology and Metabolism, Department of Internal Medicine, and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA | en_US |
dc.contributor.affiliationother | Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA | en_US |
dc.identifier.pmid | 2123512 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28957/1/0000794.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(90)90351-Q | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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