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Phospholipid metabolism in the cochlea: Differences between base and apex

dc.contributor.authorNiedzielski, Andrew S.en_US
dc.contributor.authorSchacht, Jochenen_US
dc.date.accessioned2006-04-10T14:29:20Z
dc.date.available2006-04-10T14:29:20Z
dc.date.issued1991-12en_US
dc.identifier.citationNiedzielski, Andrew S., Schacht, Jochen (1991/12)."Phospholipid metabolism in the cochlea: Differences between base and apex." Hearing Research 57(1): 107-112. <http://hdl.handle.net/2027.42/28993>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T73-485PCWF-4B/2/582754d81a23ffa5a32b84083c548d2een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28993
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1663501&dopt=citationen_US
dc.description.abstractPhospholipid-derived second messenger systems are one of the primary means for the transduction of extracellular signals to intracellular effector sites. We have investigated the longitudinal distribution of phospholipid metabolism in the guinea pig cochlea because of increasing evidence that the apex and base process auditory signals differently. Phospholipid metabolism was assayed by measuring the incorporation of radioactive phosphate (32Pi) into lipids of the organ of Corti and the lateral wall tissues (stria vascularis and spiral ligament). 32P-labeling of total phospholipids was higher in the apex than the base, and individual phospholipids exhibited a tissue-specific base/apex distribution. Phosphatidylinositol was the most abundant of the labeled lipids in all tissues except the basal lateral wall, where phosphatidylinositol and phosphatidylcholine were labeled to a similar extent. Experiments on the availability of [32P]-ATP and other non-lipid substrates (inositol, choline, and cytidine) suggested that the base/apex distribution of phospholipid metabolism is based on differences in enzymatic activities. Additional evidence for this is an increased hydrolysis of phosphoinositides in the apex. The base/apex distribution of lipid metabolism suggests that physiological and pathological mechanisms involving phospholipids differ between the turns of the cochlea.en_US
dc.format.extent726852 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePhospholipid metabolism in the cochlea: Differences between base and apexen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid1663501en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28993/1/0000021.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-5955(91)90079-Oen_US
dc.identifier.sourceHearing Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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