First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea
dc.contributor.author | Pujol, Remy | en_US |
dc.contributor.author | Zajic, Gary | en_US |
dc.contributor.author | Dulon, Didier | en_US |
dc.contributor.author | Raphael, Yehoash | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.date.accessioned | 2006-04-10T14:29:25Z | |
dc.date.available | 2006-04-10T14:29:25Z | |
dc.date.issued | 1991-12 | en_US |
dc.identifier.citation | Pujol, Remy, Zajic, Gary, Dulon, Didier, Raphael, Yoash, Altschuler, Richard A., Schacht, Jochen (1991/12)."First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea." Hearing Research 57(1): 129-141. <http://hdl.handle.net/2027.42/28995> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-485PCWF-4F/2/74818f15bc76a536de14ca8796004d2e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28995 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1774204&dopt=citation | en_US |
dc.description.abstract | Cochleae from fetal guinea-pigs (37 to 64 gestation days, gd) were used to correlate the appearance of motile properties of isolated outer hair cells (OHCs) with the development of specific morphological features. Both the `fast' electrically-driven and the `slow' calcium-induced motilities appeared first in OHCs from basal turn of 52 gd fetuses. At 56 gd, most of basal and some apical OHCs responded positively to both types of stimulation. All tested cells were positive at 64 gd. It is noteworthy that this period closely corresponds to the onset and maturation of the gross cochlear potentials. Some structural changes in the organ of Corti may be correlated with the development of OHC motile properties: the acquisition of an adult-like cylindrical shape by the OHC, its lateral detachment from neighboring Deiters cells, and its surrounding by fluid spaces. At the ultrastructural level, the formation of a first layer of laminated cisternae regularly aligned along the OHC plasma membrane from the cuticular plate down to the nuclear level, temporally coincided with the onset of in vitro motility (52 gd). The following days, pillars and a sub-membrane lattice were clearly noticed between the outermost cisternal membrane and the plasma membrane. The results support the ideas that: motile properties observed in vitro reflect the in vivo active mechanisms, and that one single layer of laminated cisternae and its associated sub-plasma membrane material may be needed for OHC motility. | en_US |
dc.format.extent | 1984814 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A.; INSERM U-254, Hôpital St. Charles, Montpellier, France. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A.; INSERM U-229, Hôpital Pellegrin, Bordeaux, France. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 1774204 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28995/1/0000023.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(91)90082-K | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.