The effects of four days of continuous striatal microdialysis on indices of dopamine and serotonin neurotransmission in rats
dc.contributor.author | Robinson, Terry E. | en_US |
dc.contributor.author | Camp, Dianne M. | en_US |
dc.date.accessioned | 2006-04-10T14:29:35Z | |
dc.date.available | 2006-04-10T14:29:35Z | |
dc.date.issued | 1991-12 | en_US |
dc.identifier.citation | Robinson, Terry E., Camp, Dianne M. (1991/12)."The effects of four days of continuous striatal microdialysis on indices of dopamine and serotonin neurotransmission in rats." Journal of Neuroscience Methods 40(2-3): 211-222. <http://hdl.handle.net/2027.42/28999> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T04-484M8MX-92/2/cfbf7364731e3ab697177af400ac193e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28999 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1724788&dopt=citation | en_US |
dc.description.abstract | The effects of 4 days of continuous microdialysis with a small-diameter concentric-style probe on indices of striatal dopamine (DA) and serotonin neurotransmission were assessed. It was found that over 4 days of dialysis, there was a marked time-dependent decrease in the basal concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in dialysate and in amphetamine-stimulated DA release. In contrast, there was no decrease in basal DA or in the ability of cocaine to elevate the concentration of DA in dialysate over the same period of time. There were only very modest changes in dialysate levels of the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), relative to the marked changes in DA metabolites. It is suggested that 4 days of continuous dialysis does not result in a non-specific decrease in diffusibility of these compounds into the dialysis probe, but that the changes are more likely due to probe-induced damage to the nigrostriatal DA system. It is also suggested that a "stable" basal concentration of DA in dialysate is an especially poor indicator of the integrity of the dopaminergic input to the striatum. The implications of these findings for within-subjects design microdialysis experiments are discussed. | en_US |
dc.format.extent | 1024558 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effects of four days of continuous striatal microdialysis on indices of dopamine and serotonin neurotransmission in rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 1724788 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28999/1/0000028.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0270(91)90070-G | en_US |
dc.identifier.source | Journal of Neuroscience Methods | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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