Anti-tumor necrosis factor antibody augments edema formation in caerulein-induced acute pancreatitis,
dc.contributor.author | Guice, Karen S. | en_US |
dc.contributor.author | Oldham, Keith T. | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.date.accessioned | 2006-04-10T14:30:18Z | |
dc.date.available | 2006-04-10T14:30:18Z | |
dc.date.issued | 1991-12 | en_US |
dc.identifier.citation | Guice, K. S., Oldham, K. T., Remick, D. G., Kunkel, S. L., Ward, P. A. (1991/12)."Anti-tumor necrosis factor antibody augments edema formation in caerulein-induced acute pancreatitis,." Journal of Surgical Research 51(6): 495-499. <http://hdl.handle.net/2027.42/29016> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNG3F0-WW/2/9ed92aebd36df4385aaf41621c48f500 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29016 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1943086&dopt=citation | en_US |
dc.description.abstract | The pathogenesis of acute pancreatitis is incompletely defined, but the outcome is determined in part by an acute inflammatory process. Pancreatitis-associated inflammation appears to play a role in the local retroperitoneal injury as well as in the associated dysfunction of remote organs such as the lung. Tumor necrosis factor (TNF) appears to be a proximal mediator of the inflammatory response. In this study, anti-TNF antibody was administered to rats with caerulein-induced pancreatitis to determine if the observed increases in pancreatic and pulmonary microvascular permeability were related to plasma TNF activity. In contrast to the expected findings, blockade of TNF activity was found to increase the amount of edema formation in both the pulmonary and pancreatic microvascular beds. The mechanism is not known; however, blockade of TNF-induced down regulation of phagocytic cell activity, ablation of TNF-dependent feedback inhibition of other cytokines, failure of induction of endogenous antioxidant systems, or inactivation of the TNF control of microvascular tone are all possible explanations. This is potentially an important observation as clinical strategies are now being developed to modify the inflammatory response in ways presumed advantageous to an injured host. | en_US |
dc.format.extent | 560421 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Anti-tumor necrosis factor antibody augments edema formation in caerulein-induced acute pancreatitis, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Sections of General Surgery and Pediatric Surgery, the University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Sections of General Surgery and Pediatric Surgery, the University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Surgery and Pathology, the University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Surgery and Pathology, the University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Surgery and Pathology, the University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 1943086 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29016/1/0000045.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(91)90171-H | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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