Tetrahydroaminoacridine (THA) reduces voltage-dependent calcium currents in rat sensory neurons
dc.contributor.author | Kelly, Kevin M. | en_US |
dc.contributor.author | Gross, Robert A. | en_US |
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.date.accessioned | 2006-04-10T14:31:00Z | |
dc.date.available | 2006-04-10T14:31:00Z | |
dc.date.issued | 1991-11-11 | en_US |
dc.identifier.citation | Kelly, Kevin M., Gross, Robert A., Macdonald, Robert L. (1991/11/11)."Tetrahydroaminoacridine (THA) reduces voltage-dependent calcium currents in rat sensory neurons." Neuroscience Letters 132(2): 247-250. <http://hdl.handle.net/2027.42/29032> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485RNMY-1N2/2/782df544975a1fc79042e4eb48ee0867 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29032 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1784428&dopt=citation | en_US |
dc.description.abstract | Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that also interacts with neuronal K+ and Na+ channels and cardiac Ca2+ channels. The effects of THA on neuronal voltage-dependent Ca2+ channels are not known. We tested the effects of THA (25 nM-250 [mu]M) on the Ca2+ current components of acutely dissociated rat nodose ganglion and dorsal root ganglion (DRG) neurons using the whole cell patch clamp recording technique. THA reduced the low-threshold (T) and high-threshold (N/L) Ca2+ current components in a concentration-dependent manner (IC50 [congruent with] 125 [mu]M for T; [congruent with] 80 [mu]M for (N/L). Minimal current reduction was seen below ~ 10 [mu]M. Our results show that THA reduces voltage-dependent Ca2+ currents in rodent sensory neurons suggesting another means by which THA may affect Ca2+-dependent physiologic processes. | en_US |
dc.format.extent | 366209 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Tetrahydroaminoacridine (THA) reduces voltage-dependent calcium currents in rat sensory neurons | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, U.S.A.; Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.identifier.pmid | 1784428 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29032/1/0000064.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(91)90312-H | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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