A novel device for chronic intracranial drug delivery via microdialysis
dc.contributor.author | Bazzett, Terence J. | en_US |
dc.contributor.author | Becker, Jill B. | en_US |
dc.contributor.author | Albin, Roger L. | en_US |
dc.date.accessioned | 2006-04-10T14:31:19Z | |
dc.date.available | 2006-04-10T14:31:19Z | |
dc.date.issued | 1991-11 | en_US |
dc.identifier.citation | Bazzett, T. J., Becker, J. B., Albin, R. L. (1991/11)."A novel device for chronic intracranial drug delivery via microdialysis." Journal of Neuroscience Methods 40(1): 1-8. <http://hdl.handle.net/2027.42/29039> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T04-484MD8Y-6N/2/74a19c8b537fe19f07fa2b5b79378a93 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29039 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1839046&dopt=citation | en_US |
dc.description.abstract | A system is described for chronic intracranial drug administration in the rat using a modified in vivo microdialysis probe coupled to an Alzet model 2002 osmotic minipump. The results presented demonstrate that this system can be used for the chronic administration of quinolinic acid with minimal non-specific damage. Each pump delivered approximately 225 [mu]l of solution over a period of 19-20 days when tested in vitro. The dialysis units were uniform in function, delivering > 93% of the [3H]quinolinic acid initially loaded into the minipump. For in vivo analysis of this apparatus the dose of quinolinic acid tested produced extensive destruction of the striatum. The present system allows reliable drug diffusion over a relatively large area without pressure injection variability. In conclusion, we have developed a simple and inexpensive technique for administration of drugs into brain parenchyma with substantial advantages over previously used techniques. | en_US |
dc.format.extent | 606046 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A novel device for chronic intracranial drug delivery via microdialysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, Neuroscience and Reproductive Sciences Programs, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A.; Department of Neurology, Neuroscience Program, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychology, Neuroscience and Reproductive Sciences Programs, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, Neuroscience Program, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.identifier.pmid | 1839046 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29039/1/0000072.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0270(91)90111-C | en_US |
dc.identifier.source | Journal of Neuroscience Methods | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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