Mannose 6-phosphate potentiates insulin-like growth factor II effects in cultured human neuroblastoma cells
dc.contributor.author | Feldman, Eva L. | en_US |
dc.contributor.author | Randolph, Ann E. | en_US |
dc.date.accessioned | 2006-04-10T14:33:21Z | |
dc.date.available | 2006-04-10T14:33:21Z | |
dc.date.issued | 1991-10-18 | en_US |
dc.identifier.citation | Feldman, Eva L., Randolph, Ann E. (1991/10/18)."Mannose 6-phosphate potentiates insulin-like growth factor II effects in cultured human neuroblastoma cells." Brain Research 562(1): 111-116. <http://hdl.handle.net/2027.42/29085> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-484MFNJ-3BP/2/9a04bce258e62e0cb7a79c5c53f48c2a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29085 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1799864&dopt=citation | en_US |
dc.description.abstract | Insulin-like growth factor II (IGF-II) and mannose 6-phosphate (man-6-P) bind to distinct sites on the same receptor4,16,20. In the present study, we examined the effects of man-6-P on the growth promoting effects of IGF-II on SH-SY5Y cultured human neuroblastoma cells. Man-6-P alone increased cell number and neurite outgrowth by approximately 50%; as previously observed12,18,27,30, IGF-II increased cell number and neurite outgrowth by approximately 110 and 30%, respectively. However, when cells were grown in the presence of both ligands, cell number increased by 330% and neurite outgrowth by 130%. These results suggest that man-6-P can potentiate the known growth promoting effects of IGF-II on human neuroblastoma cells. Furthermore, they indicate that the IGF-II/man-6-P receptor may serve as a means of integrating distinct growth promoting signals in neuronal cells. | en_US |
dc.format.extent | 616485 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mannose 6-phosphate potentiates insulin-like growth factor II effects in cultured human neuroblastoma cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Neuroscience Laboratory, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, Neuroscience Laboratory, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.identifier.pmid | 1799864 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29085/1/0000120.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(91)91194-6 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.