Characterization of o,p'-DDT-stimulated contraction frequency in rat uterus in vitro
dc.contributor.author | Juberg, Daland R. | en_US |
dc.contributor.author | Webb, R. Clinton | en_US |
dc.contributor.author | Loch-Caruso, Rita | en_US |
dc.date.accessioned | 2006-04-10T14:34:26Z | |
dc.date.available | 2006-04-10T14:34:26Z | |
dc.date.issued | 1991-10 | en_US |
dc.identifier.citation | Juberg, Daland R., Webb, R. Clinton, Loch-Caruso, Rita (1991/10)."Characterization of o,p'-DDT-stimulated contraction frequency in rat uterus in vitro." Fundamental and Applied Toxicology 17(3): 543-549. <http://hdl.handle.net/2027.42/29112> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WFT-4DDNR1F-61/2/a65722f39a7737b8ad113d3eceb42eab | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29112 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1794656&dopt=citation | en_US |
dc.description.abstract | Exposure to organochlorine pesticides, including DDT, has previously been associated with premature birth. Using an improved protocol to characterize dose and time dependent responses, the present report extends a preliminary finding by this laboratory that o,p'-DDT directly stimulates uterine contractility. Contraction frequency was determined in longitudinal uterine strips from pregnant rats under isometric force conditions. Following equilibration, the uterine strips were monitored for a 1-hr baseline period, then treated with o,p'-DDT or ethanol (solvent control) for 3 hr, followed by 3 hr without test substance. During exposure to 100 [mu] o,p'-DDT, the frequency of contraction significantly increased by 66% relative to matched controls. After removal of o,p'-DDT from the medium, the frequency of contraction continued to increase in uterine strips exposed to 50 and 100 [mu] o,p'-DDT. A dose effect was clearly observed during the post-treatment period, with 50 and 100 [mu] o,p'-DDT significantly increasing contraction frequency by 39 and 104% relative to controls. No significant differences in contraction frequency were observed with 10 [mu] o,p'-DDT during any test period. These data show that o,p'-DDT directly stimulated isometric contractions in rat uterine strips. | en_US |
dc.format.extent | 643222 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Characterization of o,p'-DDT-stimulated contraction frequency in rat uterus in vitro | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Toxicology Program, Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109-2029, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109-2029, USA | en_US |
dc.contributor.affiliationum | The Toxicology Program, Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109-2029, USA | en_US |
dc.identifier.pmid | 1794656 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29112/1/0000150.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0272-0590(91)90204-H | en_US |
dc.identifier.source | Fundamental and Applied Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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