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Involvement of Op18 in cell proliferation

dc.contributor.authorMelhem, R. F.en_US
dc.contributor.authorStrahler, John R.en_US
dc.contributor.authorHailat, Nabilen_US
dc.contributor.authorZhu, X. X.en_US
dc.contributor.authorHanash, Samir M.en_US
dc.date.accessioned2006-04-10T14:34:53Z
dc.date.available2006-04-10T14:34:53Z
dc.date.issued1991-09-30en_US
dc.identifier.citationMelhem, R. F., Strahler, J. R., Hailat, N., Zhu, X. X., Hanash, S. M. (1991/09/30)."Involvement of Op18 in cell proliferation." Biochemical and Biophysical Research Communications 179(3): 1649-1655. <http://hdl.handle.net/2027.42/29123>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DXRY44-2GN/2/438ff7016d9662ed8a1638433d34493fen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29123
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1930203&dopt=citationen_US
dc.description.abstractOp18 is a highly conserved major cytosolic phosphoprotein that is expressed at high livels in acute leukemia and in neuroblastoma. In this study we present evidence pointing to a role for Op18 in cellular proliferation. Blocking of Op18 mRNA translation using antisense oligonucleotides delayed entrance of mitotically stimulated normal peripheral blood lymphocytes into the S phase. Moreover treatment of HL-60 promyelocytic leukemia cells with DMSO or PMA which induced terminal differentiation resulted in a decrease in the level of Op18 RNA and protein. Inhibition of lymphoid proliferation with cyclosporin also resulted in reduced Op18 levels.en_US
dc.format.extent1953149 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInvolvement of Op18 in cell proliferationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, R4451 Kresge I, Ann Arbor, MI, 48109-0510, USA.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, R4451 Kresge I, Ann Arbor, MI, 48109-0510, USA.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, R4451 Kresge I, Ann Arbor, MI, 48109-0510, USA.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, R4451 Kresge I, Ann Arbor, MI, 48109-0510, USA.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, R4451 Kresge I, Ann Arbor, MI, 48109-0510, USA.en_US
dc.identifier.pmid1930203en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29123/1/0000162.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(91)91764-4en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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