A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC
dc.contributor.author | Shukla, Hridayabhiranjan | en_US |
dc.contributor.author | Gillespie, Gerald A. | en_US |
dc.contributor.author | Srivastava, Rakesh | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.contributor.author | Chorney, Michael J. | en_US |
dc.date.accessioned | 2006-04-10T14:38:48Z | |
dc.date.available | 2006-04-10T14:38:48Z | |
dc.date.issued | 1991-08 | en_US |
dc.identifier.citation | Shukla, Hridayabhiranjan, Gillespie, Gerald A., Srivastava, Rakesh, Collins, Francis, Chorney, Michael J. (1991/08)."A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC." Genomics 10(4): 905-914. <http://hdl.handle.net/2027.42/29217> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DXB8RP-3B/2/b438ed7158efb8674264ee116b421027 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29217 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1916822&dopt=citation | en_US |
dc.description.abstract | By the combination of cosmid cloning, chromosomal jumping, and pulsed-field gel electrophoresis (PFGE), we have fine-mapped the HLA-A subregion of the human major histocompatibility complex (MHC). Through the isolation of a class I jumping clone, the Qa-like HLA-G class I gene has been placed within 100 kb of HLA-H. The tight physical linkage of these class I genes has been further supported by hybridizing PFGE blots with locus-specific probes. It has been found that both of the above class I genes are linked to HLA-A, with HLA-H residing no more than 200 kb from the HLA-A gene. These data support the possible existence of a Qa-like subregion composed of nonclassical HLA class I genes within the human MHC linked telomerically to the HLA-A locus. | en_US |
dc.format.extent | 3803245 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationother | Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA | en_US |
dc.contributor.affiliationother | Department of internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA | en_US |
dc.contributor.affiliationother | Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. | en_US |
dc.identifier.pmid | 1916822 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29217/1/0000272.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(91)90178-H | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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