Effect of depolarization on striatal amino acid efflux in perinatal rats: An in vivo microdialysis study
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.contributor.author | Naik, Bina | en_US |
dc.date.accessioned | 2006-04-10T14:39:20Z | |
dc.date.available | 2006-04-10T14:39:20Z | |
dc.date.issued | 1991-07-08 | en_US |
dc.identifier.citation | Silverstein, Faye S., Naik, Bina (1991/07/08)."Effect of depolarization on striatal amino acid efflux in perinatal rats: An in vivo microdialysis study." Neuroscience Letters 128(1): 133-136. <http://hdl.handle.net/2027.42/29230> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485TW6B-3R4/2/f0a37e95a35cf472632fdb7bdfffec53 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29230 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1922942&dopt=citation | en_US |
dc.description.abstract | We used in vivo microdialysis to determine if infusion of depolarizing concentrations of potassium stimulated striatal excitatory amino acid (EAA) efflux in post-natal day (PND) 7 rats. Dialysis probes were perfused with 100 mM KCl for 60 min (n = 6); EAA efflux was unaffected until 40-60 min after onset of the infusion, when a trend towards increased EAA efflux was observed (glutamate 284 +/- 56% of baseline). In animals exposed to 8% oxygen (n = 7) before a more prolonged (100 min) KCl infusion, again over the first 40 min of KCl there were no changes in EAA efflux; subsequently, glutamate, aspartate and taurine efflux increased (peak values 682 +/- 187%, 228 +/- 32%, and 1208 +/- 437% of baseline). These data suggest that in PND 7 rats a substantial contribution to basal striatal EAA efflux may be derived from non-neurotransmitter pools. | en_US |
dc.format.extent | 410939 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of depolarization on striatal amino acid efflux in perinatal rats: An in vivo microdialysis study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 1922942 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29230/1/0000285.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(91)90777-Q | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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