Electrophysiological actions of VIP in rat somatosensory cortex
dc.contributor.author | Sessler, Francis M. | en_US |
dc.contributor.author | Grady, Steve M. | en_US |
dc.contributor.author | Waterhouse, Barry D. | en_US |
dc.contributor.author | Moises, Hylan C. | en_US |
dc.date.accessioned | 2006-04-10T14:40:43Z | |
dc.date.available | 2006-04-10T14:40:43Z | |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Sessler, Francis M., Grady, Steve M., Waterhouse, Barry D., Moises, Hylan C. (1991)."Electrophysiological actions of VIP in rat somatosensory cortex." Peptides 12(4): 715-721. <http://hdl.handle.net/2027.42/29264> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0M-47T2W9B-9P/2/f32303e67c73254312eeb9bd13f0bf5d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29264 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1788134&dopt=citation | en_US |
dc.description.abstract | Electrophysiological and biochemical studies suggest that VIP may exert a facilitating action in the neocortical local circuitry. In the present study, we examined the actions of VIP and VIP + norepinephrine (NE) on somatosensory cortical neuron responses to direct application of the putative transmitters acetylcholine (ACh) and gamma-aminobutyric acid (GABA). Spontaneous and transmitter-induced discharges of cortical neurons from halothane-anesthetized rats were monitored before, during and after VIP, NE and VIP + NE iontophoresis. In 57 VIP-sensitive cells tested, VIP application (5-70 nA) increased (n = 18), decreased (n = 36) or had biphasic actions (n = 3) on background firing rate. In a group of 20 neurons tested for NE + VIP, the combined effect of both peptide and bioamine was predominantly (70%) inhibitory. On the other hand, inhibitory and excitatory responses of cortical neurons to GABA (11 of 15 cases) and ACh (10 of 18 cases), respectively, were enhanced during VIP iontophoresis. Concomitant application of VIP and NE produced additive (n = 2) or more than additive (n = 3) enhancing effects on GABA inhibition. NE administration reversed or enhanced further VIP modulatory actions on ACh-induced excitation. These findings provide electrophysiological evidence that NE and VIP afferents may exert convergent influences on cortical neuronal responses to afferent synaptic inputs such that modulatory actions are anatomically focused within the cortex. | en_US |
dc.format.extent | 697846 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Electrophysiological actions of VIP in rat somatosensory cortex | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102-1192, USA | en_US |
dc.contributor.affiliationother | Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102-1192, USA | en_US |
dc.contributor.affiliationother | Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102-1192, USA | en_US |
dc.identifier.pmid | 1788134 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29264/1/0000322.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0196-9781(91)90124-8 | en_US |
dc.identifier.source | Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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