Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1
dc.contributor.author | Chant, John | en_US |
dc.contributor.author | Corrado, Kathleen | en_US |
dc.contributor.author | Pringle, John R. | en_US |
dc.contributor.author | Herskowitz, Ira | en_US |
dc.date.accessioned | 2006-04-10T14:41:07Z | |
dc.date.available | 2006-04-10T14:41:07Z | |
dc.date.issued | 1991-06-28 | en_US |
dc.identifier.citation | Chant, John, Corrado, Kathleen, Pringle, John R., Herskowitz, Ira (1991/06/28)."Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1." Cell 65(7): 1213-1224. <http://hdl.handle.net/2027.42/29274> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WSN-4C592NW-33/2/b7b032e94990da72d4018b51bc5f2bae | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29274 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1905981&dopt=citation | en_US |
dc.description.abstract | Cells of the yeast S. cerevisiae choose bud sites in an axial or bipolar spatial pattern depending on their cell type. We have identified a gene, BUD5, that resembles BUD1 and BUD2 in being required for both patterns; bud5- mutants also exhibit random budding in all cell types. The BUD5 nucleotide sequence predicts a protein of 538 amino acids that has similarity to the S. cerevisiae CDC25 product, an activator of RAS proteins that catalyzes GDP-GTP exchange. Two potential targets of BUD5 are known: BUD1 (RSR1) and CDC42, proteins involved in bud site selection and bud formation, respectively, that have extensive similarity to RAS. We also show that BUD5 interacts functionally with a gene, BEM1, that is required for bud formation. This interaction provides further support for the view that products involved in bud site selection guide the positioning of a complex necessary for bud formation. | en_US |
dc.format.extent | 2256251 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology The University of Michigan, Ann Arbor, Michigan 48109-1048, USA | en_US |
dc.contributor.affiliationum | Department of Biology The University of Michigan, Ann Arbor, Michigan 48109-1048, USA | en_US |
dc.contributor.affiliationother | Programs in Genetics and Cell Biology Department of Biochemistry and Biophysics University of California, San Francisco, San Francisco, California 94143, USA | en_US |
dc.contributor.affiliationother | Programs in Genetics and Cell Biology Department of Biochemistry and Biophysics University of California, San Francisco, San Francisco, California 94143, USA | en_US |
dc.identifier.pmid | 1905981 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29274/1/0000333.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0092-8674(91)90016-R | en_US |
dc.identifier.source | Cell | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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